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WithdrawnNCT01297426Leptin signaliUpdated Dec 24, 2015

Leptin Signaling in Lean and Obese Humans

An observational study in Obesity, sponsored by VA Office of Research and Development. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-24.

Sponsored by VA Office of Research and Development · Observational

Why this study was withdrawn
funding expired
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
0
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Obesity does not respond to high circulating levels of the hormone leptin. This study is aiming at finding out why this happens and open new avenues for treatment of obesity.

Read the detailed description

Ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

02

Conditions studied

  • Obesity
03

In context

Lead sponsor

VA Office of Research and Development is the lead sponsor of 1,733 studies on the registry; 396 are open to participants now.

Of its 206 completed or terminated interventional studies of FDA-regulated products, 180 (87%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

diabetic or nondiabetic lean and obese subjects

Inclusion criteria

  • men and women
  • ages 18 to 65
  • BMI ranges between 20 and 45 kg/m2

Exclusion criteria

Exclusion Criteria:

  • subjects requiring special diets
  • history of illness other than obesity of diabetes
  • taking medications known to influence glucose metabolism
  • subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents
  • women who are breastfeeding, pregnant or wanting to become pregnant
  • subjects with bleeding dyscrasia or poor wound healing
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
0 participants (actual)

Groups and cohorts

  • Group 1

    Lean and obese, diabetic and non diabetics

06

What researchers measure

Primary outcomes

  1. Westerns / activation of signaling pathways (uo to two hours after treatment)

    Time frame: 04/01/2016

07

Study locations

1 site
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
    Boston, Massachusetts 02130, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 24, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01297426
Lead sponsor
VA Office of Research and Development
Responsible party
Sponsor
First posted
Feb 16, 2011
Start date
Apr 2011
Primary completion
Jun 2015
Completion
Jun 2015
Last update
Dec 24, 2015

Study contacts

Christos Mantzoros, MD DSc
principal investigator · VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.

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