CClinicalTrials.gg
CompletedNCT01274052Updated Jan 11, 2011

Study of Postprandial Incretin Response in Women With Gestational Diabetes

An observational study in Gestational Diabetes Mellitus, sponsored by University Hospital, Gentofte, Copenhagen. Completed at 1 site in Denmark. Open to female participants. Per ClinicalTrials.gov, last updated 2011-01-11.

Sponsored by University Hospital, Gentofte, Copenhagen · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
19
Sex
Female
01

Study summary

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

Read the detailed description

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

02

Conditions studied

  • Gestational Diabetes Mellitus

Keywords

  • Gestational diabetes mellitus
  • Meal test
  • Incretin hormones
  • Glucagon-like peptide-1 (GLP-1)
  • Glucose-dependent insulinotropic polypeptide
  • Insulin
  • C-peptide
  • Glucagon
03

In context

Diabetes, Gestational

842 studies on the registry are indexed under Diabetes, Gestational; 198 are open to participants now.

This study's enrollment of 19 is below the median of 200 across 269 observational studies indexed under Diabetes, Gestational.

Browse Diabetes, Gestational studies →

Lead sponsor

University Hospital, Gentofte, Copenhagen is the lead sponsor of 154 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Healthy pregnant woman were examined with a 75 g oral glucose tolerance test. Subjects with plasma glucose (PG) values at 120 min >9.0 mmol/l were diagnosed with gestational diabetes and subjects with PG \<9.0 mmol/l were enrolled as healthy controls.

Inclusion criteria

  • Normal haemoblobin
  • Willingness to participate

Exclusion criteria

Exclusion Criteria:

  • First degree relative with diabetes
  • Diabetes before pregnancy
  • Positive islet cell- and GAD-65 autoantibodies
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
19 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • Gestational Diabetes Mellitus

    Women with Gestational Diabetes Mellitus

    Other: Meal test

  • Normal Glucose Tolerance

    Women with Normal Glucose Tolerance

    Other: Meal test

Interventions

  • OtherMeal test

    Liquid meal test

06

Study locations

1 site
  • Department of Internal Medicine, Glostrup Hospital
    Glostrup, 2600, Denmark
07

References and documents

Publications

  • Hare KJ, Bonde L, Svare JA, Randeva HS, Asmar M, Larsen S, Vilsboll T, Knop FK. Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabet Med. 2014 Aug;31(8):936-40. doi: 10.1111/dme.12436. Epub 2014 Apr 1. PubMed 24628007 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 11, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01274052
Lead sponsor
University Hospital, Gentofte, Copenhagen
Collaborators
The Danish Diabetes Association, Aase and Ejnar Danielsens Foundation, The Novo Nordic Foundation
First posted
Jan 11, 2011
Start date
Mar 2007
Primary completion
Jul 2008
Completion
Jul 2008
Last update
Jan 11, 2011

Study contacts

Filip K Knop, MD PhD
principal investigator · Diabetes Research Division, Gentofte Hopsital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2011. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion