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RecruitingNCT01255748Updated Sep 29, 2026

Registry Study for Radiation Therapy Outcomes

An observational study in Neoplasms, sponsored by Proton Collaborative Group. Recruiting at 29 sites in United States. Per ClinicalTrials.gov, last updated 2026-09-29.

Sponsored by Proton Collaborative Group · Observational

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Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50,000
Sex
All
01

Study summary

The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.

02

Conditions studied

  • Neoplasms

Browse trials for

Keywords

  • cancer, proton, radiation
03

In context

Neoplasms

10,824 studies on the registry are indexed under Neoplasms; 2,325 are open to participants now.

This study's planned enrollment of 50,000 is above the median of 200 across 2,641 observational studies indexed under Neoplasms.

Browse Neoplasms studies →

Lead sponsor

Proton Collaborative Group is the lead sponsor of 10 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Radiation Oncology patients

Eligibility criteria

Inclusion Criteria:

  • Planned treatment with radiation therapy
  • Ability to understand and sign IRB approved consent
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50,000 participants (estimated)
Target follow-up
30 Years
Patient registry
Yes

Groups and cohorts

  • Treatment with Radiation Therapy

    Includes 16 different arms to capture patient data by disease site

    Radiation: Proton Therapy, Photon Therapy, SRS, Brachytherapy

Interventions

  • RadiationProton Therapy, Photon Therapy, SRS, Brachytherapy

    Outcomes Tracking

06

What researchers measure

Primary outcomes

  1. Define outcomes for patients treated at participating institutions

    Time frame: PRN

Secondary outcomes

  1. Determine strategies necessary to improve patients outcome and decrease toxicities related to treatments and procedures

    Time frame: Annually PRN

  2. Improve patient care by an adequate understanding of the results and patient population at participating institutions

    Time frame: Reviewed Annually PRN

07

Study locations

29 of 29 sites recruiting
08

References and documents

Publications

  • Lee HJ Jr, Macomber MW, Spraker MB, Bowen SR, Hippe DS, Fung A, Russell KJ, Laramore GE, Rengan R, Liao J, Apisarnthanarax S, Zeng J. Early toxicity and patient reported quality-of-life in patients receiving proton therapy for localized prostate cancer: a single institutional review of prospectively recorded outcomes. Radiat Oncol. 2018 Sep 17;13(1):179. doi: 10.1186/s13014-018-1127-6. PubMed 30223877 ↗
09

Timeline

1 registry update since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jun 2009 and a primary completion of Jun 2039. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 6, 2010
First posted
Dec 7, 2010
Start
Jun 2009
Primary completionEst.
Jun 2039
Last update
Sep 29, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Site contacts
Changed at 1 site. See the sites
Show the site
  • Miami Cancer Institute · Miami, United StatesContact a•••@baptisthealth.net · •••2000→m•••@baptisthealth.net · •••2000
Sep 29, 2026
Show all 1 update
  1. Sep 29, 2026
    Site contacts Changed at 1 site. See the sites
    Show the site
    • Miami Cancer Institute · Miami, United StatesContact a•••@baptisthealth.net · •••2000→m•••@baptisthealth.net · •••2000
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT01255748
Lead sponsor
Proton Collaborative Group
Responsible party
Sponsor
First posted
Dec 7, 2010
Start date
Jun 2009
Primary completion
Jun 2039 (estimated)
Last update
Sep 29, 2026

Study contacts

Carlos Vargas, MD
study chair · Proton Collaborative Group

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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Discussion

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