An interventional study of Inspiratory Muscle Training in Reduction of Blood Pressure in Hypertensive Patients., Improvement of Cardiovascular Autonomic Control. and Improvement of Functional Capacity., sponsored by Federal University of Health Science of Porto Alegre. Status unknown at 1 site in Brazil. Open to participants aged 30 Years to 70 Years. Per ClinicalTrials.gov, last updated 2010-11-30.
Sponsored by Federal University of Health Science of Porto Alegre · Not applicable, Interventional, and Treatment
The purpose of this study is to determine inspiratory muscle training effects on blood pressure, functional capacity and quality of life in hypertensive patients.
The interaction between respiratory function and cardiovascular system, as well as the present alterations in these systems, due to diseases such as Hypertension, diabetes and chronic heart failure, are the factors that potentially participate of the pathogenic frame in these situations. Consequently, it is so related to reduction of functional capacity, endothelial dysfunction of the sympathetic and parasympathetic cardiovascular control and morphologic alterations on the skeletal muscles, including ventilatory muscles.
On the other hand, a proinflammatory state also participates of this dysfunction and reduced function capacity situation. Cardiovascular risk factors, such as hypertension, increased heart rate variability, diabetes and heart failure explain the occurrence of the majority of cardiovascular events in the entire world and so in Brazil. Studies with experimental models and in patients with cardiovascular diseases identified important inflammatory activity associated to risk factors and preceding clinical events.
Inspiratory muscle training (IMT) shows consistent results in the improvement of functional capacity in athletes, sedentary subjects, heart failure patients and in animals submitted to an IMT model.
The study of alterations in cardiorespiratory interaction, functional capacity and cardiovascular control mechanisms (sympathetic, parasympathetic by heart rate variability), altogether, in hypertension, is a single opportunity to identify new pathogenic mechanisms involved in the reduction of functional capacity as well as promote its quantification. Therefore, the effects of IMT on these alterations are still not well understood. In this way, the response to IMT is a complement to epidemiologic and clinical models, as potential source of new possibilities in the research field.
1,092 studies on the registry are indexed under Respiratory Aspiration; 216 are open to participants now.
This study's planned enrollment of 14 is below the median of 42 across 881 interventional studies indexed under Respiratory Aspiration.
Browse Respiratory Aspiration studies →Federal University of Health Science of Porto Alegre is the lead sponsor of 118 studies on the registry; 19 are open to participants now.
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2.1. Prehypertension - Systolic blood pressure (SBP) of 120 to 139 and/or diastolic blood pressure (DBP) of 80 to 89 mmHg 2.2.Stage 1 Hypertension - SBP of 140 to 159 mmHg and/or DBP of 90 to 99 mmHg 2.3.Stage 2 Hypertension - SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg
Exclusion Criteria:
It will me performed a loaded training of ventilatory muscles in patients with Hypertension. Its is done with the practice of breathing exercises associated to an training device, specific for this kind of intervention.
Other: Inspiratory Muscle Training
Breathing exercises associated to the use of a training device with predetermined pressure load, daily, 30 minutes per day, during eight weeks.
Differences on blood pressure levels
Blood pressure behavior is accessed by Ambulatory Blood Pressure Monitorying.
Time frame: eight weeks
improvement of Heart rate variability
Time frame: eight weeks
improvement of quality of life
To measure the quality of life, it is used the SF36 short form questionary.
Time frame: eigth weeks
Improvement of Functional Capacity
It is measure by the oxytgen consumption accessed by ergospirometry.
Time frame: eight weeks
This study is status unknown, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.
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Federal University of Health Science of Porto Alegre