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Status unknownNCT01243840J-CARPUpdated Jan 25, 2012

Japan Central Aortic Pressure Prospective Study

An observational study in Healthy, sponsored by Yoshio Matsui. Status unknown at 1 site in Japan. Open to participants aged 20 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-01-25.

Sponsored by Yoshio Matsui · Observational

The sponsor has not verified this record recently (last verified Jun 2010), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,000
Ages
20 Years to 90 Years
Sex
All
01

Study summary

Purpose of the study

  1. The predictive value of central aortic pressure and aortic pulse wave velocity (PWV) in a Japanese population is not known. The purpose of this study is to quantify the predictive value of these indices in the determination of cardiovascular risk.
  2. Recently, a non-invasive method to separate the aortic pressure waveform into the separate ejection pressure wave and reflected pressure wave has become available. With this decomposition method, it is possible to estimate aortic PWV (named AVI). The second objective of this study is to determine if AVI can be a substitute for carotid-femoral PWV (cf-PWV), the current gold standard for aortic PWV measurement.
  3. To study vascular aging of the Japanese population by evaluating central blood pressure and aortic PWV by age, and compare these values to similar studies done in Caucasian and Chinese patient populations.
  4. To study the relationship between the magnitude of the aortic reflected pressure wave and the degree of left ventricular (LV) hypertrophy and LV diastolic function.
02

Conditions studied

  • Healthy

Keywords

  • Central aortic pressure
  • Aortic pulse wave velocity
  • Aortic PWV using a single pressure recording
  • Vascular aging
  • Left ventricular hypertrophy
  • Left ventricular diastolic function
03

In context

Lead sponsor

Yoshio Matsui is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Ages eligible for Study: 20 Years to 90 Years Genders eligible for Study: Both Accepts healthy volunteers: Yes

Inclusion criteria

  • Subjects who visit hospital for their health checks
  • Healthy volunteers who agree to participate in this study

Exclusion criteria

Exclusion Criteria:

  • History of coronary artery disease, cerebrovascular disease, congestive heart failure, aortic dissection
  • Subjects taking vasoactive drugs (antihypertensive and/or nitrates)
  • Atrial fibrillation or atrial flutter
  • Renal dysfunction (serum creatinine ≥3 mg/dl)
  • Type I diabetes mellitus
  • Hepatic dysfunction (AST and/or ALT ≥100 IU/l)
  • A history of malignant tumor within 5 years of enrollment or suspected
  • Pregnancy, possible pregnancy
  • Chronic inflammation disease
  • Not suited to the clinical trial as judged by a collaborating physician
  • Inability to give informed consent
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,000 participants (estimated)
06

What researchers measure

Primary outcomes

  1. •Composite of following events: sudden death, cardiovascular death, stroke, coronary events, heart failure

    Time frame: 5 years

Secondary outcomes

  1. New onset of hypertension, diabetes mellitus, or atrial fibrillation

    Time frame: 5 years

07

Study locations

1 of 1 sites recruiting
  • Iwakuni City Medical Center
    Iwakuni, Yamaguchi 740-0021, Japan
    • Yoshio Matsui · Contact · yoshio@jichi.ac.jp · +81-827-21-3211
    • Yoshio Matsui, MD · Principal investigator
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 25, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01243840
Lead sponsor
Yoshio Matsui
Responsible party
Yoshio Matsui (Sponsor-Investigator, Jichi Medical University) — Sponsor-investigator
First posted
Nov 19, 2010
Start date
Jun 2010
Primary completion
Jun 2014 (estimated)
Completion
Jun 2019 (estimated)
Last update
Jan 25, 2012

Study contacts

Kazuomi Kario, MD
study director · Jichi Medical University School of Medicine

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.

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