ClinicalTrials.gg
Status unknownNCT01242137Updated Nov 16, 2010

Pharmacogenetic Effect on the Pharmacodynamics of Glibenclamide

An observational study in Diabetes, sponsored by Assaf-Harofeh Medical Center. Status unknown at 1 site in Israel. Open to participants aged 20 Years to 90 Years. Per ClinicalTrials.gov, last updated 2010-11-16.

Sponsored by Assaf-Harofeh Medical Center · Observational

The sponsor has not verified this record recently (last verified Oct 2010), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
30
Ages
20 Years to 90 Years
Sex
All
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Study summary

Glibenclamide is metabolized by the hepatic enzyme P450 CYP2C9 to less active form. Polymorphism of this enzyme demonstrated clinical significance when examined on other drugs from the sulfonylurea drug family, to whom Glibenclamide is included.

The investigators assumption is that patients with less active alleles of the enzyme may show lower dose requirements of the drug for glycemic control, when compared to patients homozygotes to wild-type alleles.

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Conditions studied

  • Diabetes

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03

In context

Diabetes Mellitus

11,089 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.

This study's planned enrollment of 30 is below the median of 234 across 2,254 observational studies indexed under Diabetes Mellitus.

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Lead sponsor

Assaf-Harofeh Medical Center is the lead sponsor of 267 studies on the registry; 43 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Diabetes type 2 patients treated with metformin and glibenclamide.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Tx with metformin and glibenclamide

Exclusion criteria

Exclusion Criteria:

  • Tx which affecting the P450 2C9 action
  • Renal failure
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
30 participants (estimated)

Groups and cohorts

  • Extensive metabolizers
  • Intermediate mtabolizers
  • Poor metabolizers
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What researchers measure

Primary outcomes

  1. HbA1c

    Time frame: 2 years

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Study locations

1 of 1 sites recruiting
  • Assaf Harofe Medical Center
    Beer Yakov, Israel
    • Amit Tirosh, Dr · Contact · tiroshamit@gmail.com · 972-52-4748989
    • Amit Tirosh, Dr · Principal investigator
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 16, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01242137
First posted
Nov 16, 2010
Start date
Oct 2009
Last update
Nov 16, 2010

Study contacts

Amit Tirosh, Dr
Contact
tiroshamit@gmail.com
972-52-4748989
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.

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