A Phase 1 interventional study of Fish and shellfish in Selenium Status and Selenium Uptake From Fish and Shellfish, sponsored by Danish Cancer Society. Completed at 1 site in Denmark. Open to participants aged 50 Years to 74 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-09-29.
Sponsored by Danish Cancer Society · Phase 1, Interventional, and Basic science
The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels.
The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.
Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.
Danish Cancer Society is the lead sponsor of 22 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: Fish and shellfish
Assessment only
Intake of 1000 grams of fish and shellfish per week for six months.
Selenium concentration in whole blood
Time frame: Measured at baseline
Selenium concentration in whole blood
Time frame: Measured after 3 months of intervention
Selenium concentration in whole blood
Time frame: Measured after 6 months of intervention
Selenoprotein P in plasma
Time frame: Measured at baseline
Selenoprotein P in plasma
Time frame: Measured after 3 months of intervention
Selenoprotein P in plasma
Time frame: Measured after 6 months of intervention
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured at baseline
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured after 3 months of intervention
Genetic polymorphisms in the selenoprotein P gene
Time frame: Measured after 6 months of intervention
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured at baseline
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured after 3 months of intervention
Heavy metals in whole blood (lead, cadmium, and mercury)
Time frame: Measured after 6 months of intervention
Blood pressure
Time frame: Measured at baseline
Blood pressure
Time frame: Measured after 3 months of intervention
Blood pressure
Time frame: Measured after 6 months of intervention
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured at baseline
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured after 3 months of intervention
Anthropometry (weight, height, waist, and hip circumference)
Time frame: Measured after 6 months of intervention
This study is completed, as verified in Aug 2011. You cannot join it, but the record below documents what was studied.
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Danish Cancer Society