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CompletedNCT01220037Updated Oct 28, 2013

Resistance Exercise in Healthy Men

An interventional study of Adhere to a specific standardized diet for 4 days in Single Bout of Resistance Type Exercise and Standardized Diet, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-10-28.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
18 Years to 85 Years
Sex
Male
01

Study summary

In the present study, the effects of age and dietary intake will be assessed on myocellular characteristics during 72 hours after a resistance type exercise session.

02

Conditions studied

  • Single Bout of Resistance Type Exercise
  • Standardized Diet
03

In context

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 85 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy men between the ages of 18-30 or 70-85 years

Exclusion criteria

Exclusion Criteria:

  • Subjects with a recent history or current state of cardiovascular disease, COPD, Parkinson, rheumatoid arthritis, musculoskeletal/orthopaedic disorders, renal disorder, cognitive impairment.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Investigator, Outcomes assessor)
Enrollment
34 participants (actual)

Study arms

  • Experimental
    Young regular diet

    During the time of the study this group will adhere to a standardized regular diet.

    Behavioral: Adhere to a specific standardized diet for 4 days

  • Experimental
    Young low protein diet

    During the time of the study this group will adhere to a standardized low protein diet.

    Behavioral: Adhere to a specific standardized diet for 4 days

  • Experimental
    Young high protein

    During the time of the study this group will adhere to a standardized high protein diet.

    Behavioral: Adhere to a specific standardized diet for 4 days

  • Experimental
    Elderly

    During the time of the study this group will adhere to a standardized high protein diet

    Behavioral: Adhere to a specific standardized diet for 4 days

Interventions

  • BehavioralAdhere to a specific standardized diet for 4 days

    24 h before the start of the intervention all subjects will adhere to a standardized diet for 4 days. Young subjects are randomly allocated to either a low protein diet, regular protein diet or high protein diet group. All elderly subjects will adhere to a regular protein diet comparable to the regular protein diet of the young subjects.

06

What researchers measure

Primary outcomes

  1. Muscle fiber myonuclear and stem cell content

    Time frame: baseline

  2. Muscle fiber myonuclear and stem cell content

    Time frame: 12 hours after a single bout of resistance type exercise

  3. Muscle fiber myonuclear and stem cell content

    Time frame: 24 hours after a single bout of resistance type exercise

  4. Muscle fiber myonuclear and stem cell content

    Time frame: 48 hours after a single bout of resistance type exercise

  5. Muscle fiber myonuclear and stem cell content

    Time frame: 72 hours after a single bout resistance type exercise

07

Study locations

1 site
  • Maastricht University Medical Centre
    Maastricht, Zuid Limburg 6200MD, Netherlands
08

References and documents

Publications

  • Snijders T, Verdijk LB, McKay BR, Smeets JS, van Kranenburg J, Groen BB, Parise G, Greenhaff P, van Loon LJ. Acute dietary protein intake restriction is associated with changes in myostatin expression after a single bout of resistance exercise in healthy young men. J Nutr. 2014 Feb;144(2):137-45. doi: 10.3945/jn.113.183996. Epub 2013 Dec 4. PubMed 24306214 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 28, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01220037
Lead sponsor
Maastricht University Medical Center
Responsible party
Lex Verdijk (Dr., Maastricht University Medical Center) — Principal investigator
First posted
Oct 13, 2010
Start date
Apr 2010
Primary completion
Sep 2011
Completion
Dec 2011
Last update
Oct 28, 2013

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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