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CompletedNCT01215474Updated Jun 16, 2011

Pathomolecular Analysis of Rare EGFR Mutations in Advanced NSCLC

An observational study in Mutations in Exons 18 to 21, sponsored by Provitro GmbH. Completed at 1 site in Germany. Per ClinicalTrials.gov, last updated 2011-06-16.

Sponsored by Provitro GmbH · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
500
Sex
All
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Study summary

While current mutational analyses comprise exons 19 and 21 in which the majority of EGFR-mutations occur, this study aims at investigating the relevance of exon 18 and 20 mutations. Therefore, the investigators analyse 500 routine tumor samples with respect to the above mentioned exons and correlate the results to the clinical outcome. This approach will enable us to potentially identify patients that might in the future benefit from targeted therapy (EGFR-inhibition).

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Conditions studied

  • Mutations in Exons 18 to 21
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In context

Lead sponsor

This is the only study on the registry with Provitro GmbH as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients who were biopsied and/or received surgery for NSCLC diagnostics

Inclusion criteria

  • NSCLC Stadium III-IV

Exclusion criteria

Exclusion Criteria:

  • no NSCLC or different stadium
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Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
500 participants (actual)

Groups and cohorts

  • NSCLC Stadium III-IV
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Study locations

1 site
  • Institute of Pathology, Charité University Medicine Berlin
    Berlin, 10117, Germany
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 16, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01215474
Lead sponsor
Provitro GmbH
Collaborators
AstraZeneca, Charite University, Berlin, Germany
First posted
Oct 6, 2010
Last update
Jun 16, 2011
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.

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Discussion

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