A Phase 1 interventional study of cell injection in Bone Cyst, sponsored by Royan Institute. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 12 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-12-14.
Sponsored by Royan Institute · Phase 1, Interventional, and Treatment
There are two types of bone cysts, unicameral and aneurismal. These cysts happen to anyone, but they are most commonly seen in children and young adults while their bones are still growing. Living with a bone cyst and determining treatment options depend on the type of cyst.
Non-surgical treatments for unicameral bone cysts involves repeated X-rays in individuals who do not experience any symptoms.
Surgical removal of a unicameral bone cyst is needed if it becomes especially painful, or the area of the bone starts to thin out. The investigators aim to assess the clinical efficacy and side effects of mesenchymal stem cells seeded on bone matrix in repairing bone cyst.
Bone cysts are benign lesions usually discovered in children from age of 5 to 15 years. Treatment options include observation, corticosteroid injection and surgery. Sometimes the risk of surgery is comparable to the likelihood of fracture without treatment. In orthopedic surgery, bone chips , various types of ceramics, natural and synthetized bone mineral hydroxyapatite and tricalcium phosphate, as well as numerous polymers and co-polymers of alfa-hydroxy acids are used to perform as an osteoconductive and rarely osteoinductive factor to help bone formation.Some evidence demonstrated that bone marrow mesenchymal stem cells deposited on the surface of this constructs enhance its osteogenic differentiation. In this study the investigators seeds cultured bone marrow derived mesenchymal stem cells on bone matrix, to evaluate its therapeutic potential in repairing unicameral or aneurysmal bone cyst.This composite is placed in the bone cyst after its curettage during a surgery.Post-operation assessment is done by X-Ray examination and MRI at 1, 2, 6, and 12 months after treatment.
18 studies on the registry are indexed under Bone Cysts; 5 are open to participants now.
This study's enrollment of 6 is below the median of 17 across 10 interventional studies indexed under Bone Cysts.
Browse Bone Cysts studies →Royan Institute is the lead sponsor of 94 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Patients with bone cyst defect are injected with mesenchymal cells.
Biological: cell injection
injection of mesenchymal cells to bone cyst defect
Also known as: cell transplantation
fulfill bone cyst defect
Defect of bone due to cyst fulfill after cell transplantation.
Time frame: 6 months
effect of mesenchymal cell transplantation
Evaluate effect of mesenchymal cell transplantation to fulfill the defect of bone cyst.
Time frame: 6 months
This study is completed, as verified in Mar 2009. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Cell Types
Royan Institute