An interventional study of GLP-1 and Saline in Vagotomy, Truncal, sponsored by University Hospital, Gentofte, Copenhagen. Status unknown at 1 site in Denmark. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-12-07.
Sponsored by University Hospital, Gentofte, Copenhagen · Not applicable, Interventional, and Basic science
The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of Glucagon-like peptide-1 (GLP-1) in respect to gastric emptying, appetite and food intake.
The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the researchers will investigate individuals with and without intact nervous supply.
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of intact vagal innervations on the effect of GLP-1 on the food intake, gastric emptying (GE) and appetite.
University Hospital, Gentofte, Copenhagen is the lead sponsor of 154 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Truncally vagotomized subjects (due to duodenal ulcer operation)
Drug: GLP-1 · Other: Saline
truncally vagotomized subjects (due to esophagus resection)
Drug: GLP-1 · Other: Saline
Healthy control subjects
Drug: GLP-1 · Other: Saline
1.2 pmol/kg/min GLP-1 will be infused intravenously during the four hour meal test (100 g Ny NAN1 and 1.5 g paracetamol dissolved in 300 ml water) ingested over 10 minutes. After four hours an ad libitum meal will be supplied
Also known as: Panodil
Saline (isotonic NaCl) will be infused intravenously during the four hour meal test (100 g Ny NAN1 and 1.5 g paracetamol dissolved in 300 ml water) ingested over 10 minutes. After four hours an ad libitum meal will be supplied
Also known as: Panodil
Gastric emptying
Gastric emptying will be assessed using a liquid meal with 1.5 g paracetamol added and continuous blood sampling for measuring paracetamol concentration during four hours
Time frame: four hours
Appetite
Hunger, satiation, and fullness will be assessed before, during and after a liquid meal with 1.5 g paracetamol added using a visual analog scale (VAS)
Time frame: four hours
Food intake
After the liquid meal test, the volunteers will be offered a meal to assessed their ad libitum food intake
Time frame: five hours
plasma glucose
Time frame: four hours
serum insulin and c-peptide
Time frame: four hours
plasma glucagon
Time frame: four hours
plasma GLP-1
Time frame: four hours
endogenous GLP-1
endogenous GLP-1 will be assessed as plasma GLP-2 concentration
Time frame: four hours
plasma GIP
Time frame: four hours
serum paracetamol
Time frame: four hours
This study is status unknown, as verified in Dec 2012. You cannot join it, but the record below documents what was studied.
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University Hospital, Gentofte, Copenhagen