An interventional study of Oral glucose tolerance test and Oral lipid tolerance test in Healthy Subjects, sponsored by University College Dublin. Completed at 2 sites in Ireland. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-01-11.
Sponsored by University College Dublin · Not applicable, Interventional, and Basic science
The purpose of this study is to investigate the biological response to a metabolic stress, given in the form of a high carbohydrate or fat meal in normal weight, overweight and obese individuals and to further explore these responses using novel metabolomic, proteomic, transcriptomic and genotyping techniques.
The most recent statistics from the Department of Health in Ireland (2005) indicate that the leading causes of death are those in which nutrition can play a key preventative role. The proposed study will provide information on the metabolic stress from varying body weight overlaid by the additional metabolic stress of a test-meal challenge, in this case being delivered in the form of an oral glucose tolerance test (OGTT) and oral lipid tolerance test (OLTT), standard metabolic challenges in post-prandial research. Previous studies assessing metabolic risk factors associated with a disease have typically focused on information collected from individuals in a fasting state only. However, it is equally important to assess how the body responds when stressed. Employing an acute high fat or carbohydrate intake is sufficient to induce a mild stress in which time an individual's unique post-prandial response can be monitored. This study will combine traditional markers (dietary, anthropometric, lifestyle, clinical and physical activity) with nutrigenomics, a tool that attempts to describe the genome-wide influences of nutrition by examining the impact of diet on genes (genomics), mRNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics).
University College Dublin is the lead sponsor of 108 studies on the registry; 31 are open to participants now.
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Exclusion Criteria:
2 successive Oral Glucose Tolerance Tests followed by a physical tests session
Other: Oral glucose tolerance test
2 successive Oral Lipid Tolerance Tests followed by a physical test session
Other: Oral lipid tolerance test
Oral glucose tolerance test followed by an oral lipid tolerance test (or vice-versa) followed by a physical tests session
Other: Oral glucose tolerance test · Other: Oral lipid tolerance test
75g anhydrous glucose powder mixed with 100mls water
150ml drink composed of 2 commercially available high fat products
Comprehensive analysis of the metabolic response to the acute ingestion of fat and glucose loads
Time frame: 2-5 hours post test meal ingestion
This study is completed, as verified in Jan 2011. You cannot join it, but the record below documents what was studied.
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University College Dublin