An interventional study of magnesium sulphate and normal saline in Easy of Laryngoscopy Manipulation, Vocal Cord Position or Movement and Patient Reaction to Intubation and Cuff Inflation, sponsored by Seoul National University Bundang Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2012-01-09.
Sponsored by Seoul National University Bundang Hospital · Not applicable and Interventional
Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released at the motor nerve terminal by decreasing the calcium conductance of presynaptic voltage-dependent calcium channels. After pre-treatment with magnesium, an increased speed of onset and a prolongation of the recovery period of neuromuscular blockade have been observed with other non-depolarizing neuromuscular blocking agent (NMBA) such as atracurium, vecuronium and rocuronium. Rocuronium is the currently preferred NMBA used as an alternative to succinylcholine for rapid tracheal intubation. As an alternative to succinylcholine, high doses of NMBA have been tested for rapid sequence intubation. This excessively high dose of rocuronium, however, prolongs the duration of the neuromuscular block and this may not be warranted in every surgical setting.
The reduction of onset time of rocuronium by magnesium pre-treatment can make intubation condition more rapid and much better clinically. It will thus be interesting to compare intubation conditions of a standard intubation dose of rocuronium after magnesium pre-treatment with high dose of rocuronium or standard dose of rocuronium.
Seoul National University Bundang Hospital is the lead sponsor of 368 studies on the registry; 55 are open to participants now.
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Drug: magnesium sulphate
Drug: normal saline
Drug: normal saline
The patients of group M receive 50 mg/kg of magnesium sulphate in 100 ml of isotonic saline over 10 min immediately before anaesthesia induction. After induction of anesthesia with alfentanil (10 μg/kg) and propofol (2 mg/kg), rocuronium 0.6 mg/kg is given over 5 s in a running infusion.
Patients in the group R-0.6 receive the same volume of isotonic saline over the same period, and rocuronium 0.6 mg/kg is given after the induction of anesthesia with alfentanil (10 μg/kg) and propofol (2 mg/kg).
Patients in the group R-0.6 receive the same volume of isotonic saline over the same period, and rocuronium 0.9 mg/kg is given after the induction of anesthesia with alfentanil (10 μg/kg) and propofol (2 mg/kg).
the intubating conditions
The anesthesiologist also assessed the intubating conditions as per the intubation scoring system of the Good Clinical Research Practice guideline.
Time frame: 1 minute during intervention
mean arterial pressure (MAP)
They were recorded pre-induction (base line), just before intubation, and every minute thereafter for 5 min.
Time frame: 5 min before intubation, immediate before intubation, post-intubation 1, 2, 3, 4, and 5 min.
heart rate (HR)
They were recorded pre-induction (base line), just before intubation, and every minute thereafter for 5 min.
Time frame: 5 min before intubation, immediate before intubation, post-intubation 1, 2, 3, 4, and 5 min.
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Seoul National University Bundang Hospital