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TerminatedNCT01152944MoSISUpdated Feb 7, 2012

Mechanisms of Stroke in Intracranial Stenosis

An observational study in Stroke, sponsored by Jose Romano, MD. Terminated at 1 site in United States. Open to participants aged 30 Years to 80 Years. Per ClinicalTrials.gov, last updated 2012-02-07.

Sponsored by Jose Romano, MD · Observational

Why this study was terminated
The affiliated study SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis) has stopped enrollment.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
30 Years to 80 Years
Sex
All
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Study summary

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

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Conditions studied

  • Stroke

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Keywords

  • Symptomatic intracranial atherosclerotic disease enrolled in the medical arm of SAMMPRIS
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In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's enrollment of 100 is below the median of 160 across 1,692 observational studies indexed under Stroke.

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Lead sponsor

This is the only study on the registry with Jose Romano, MD as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
30 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Medical arm of the SAMMPRIS trial which includes recently symptomatic (\<30 days) high grade (70% or more)intracranial stenosis of the carotid, middle cerebral, vertebral or basilar arteries.

Inclusion criteria

  • Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion criteria

Exclusion Criteria:

  • For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (actual)
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What researchers measure

Primary outcomes

  1. Ischemic stroke in the territory of the stenotic artery

    Time frame: 2 years from enrollment

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Study locations

1 site
  • University of Miami
    Miami, Florida 33136, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 7, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01152944
Lead sponsor
Jose Romano, MD
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Responsible party
Jose Romano, MD (Associate Professor of Neurology. Director of Cerebrovascular Division, University of Miami) — Sponsor-investigator
First posted
Jun 29, 2010
Start date
Jul 2010
Primary completion
Apr 2011
Completion
Dec 2011
Last update
Feb 7, 2012

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Feb 2012. You cannot join it, but the record below documents what was studied.

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