An observational study in Cardiac Risk Factors, Healthy and Healthy Volunteers, sponsored by National Institutes of Health Clinical Center (CC). Recruiting at 1 site in United States. Open to participants aged 18 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by National Institutes of Health Clinical Center (CC) · Observational
Background:
- Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body. These scanning parameters are often specific to the institution or organization at which they are employed, and may also depend on the manufacturer of the MRI scanning equipment. Because MRI scanning equipment is always being updated and upgraded, researchers are interested in developing new and optimized scanning parameters for MRI scans.
Objectives:
- To improve current methods and develop new techniques for magnetic resonance imaging.
Eligibility:
Design:
Magnetic Resonance (MR) Imaging performed on volunteers will be used to develop and optimize techniques useful in the advancement of MRI technology.
National Institutes of Health Clinical Center (CC) is the lead sponsor of 376 studies on the registry; 27 are open to participants now.
Of its 23 completed or terminated interventional studies of FDA-regulated products, 19 (83%) have results posted.
Counted across the registry records on this site, refreshed daily.
Volunteers (maybe Volunteers, NIH employee and current NIH protocol participants)
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
A. Volunteer individuals
B. Lab Eligibility parameters (for contrast scans within 4 weeks of gadolinium injection):
C. Creatinine below upper normal limit
D. >= 60 mL/min/1.73m2
E. Age >= 60 or history of renal disease: test GFR within 1 week prior to contrast
F. Willing to travel to the NIH for follow-up visits.
G. 18 years old
H. Able to understand and sign
I. No MRI scan with gadolinium injection in the last 6 months under this protocol.
EXCLUSION CRITERIA:
A. Implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damages from twisting in a Magnetic field. Examples:
B. Pregnant women
C. Paralyzed hemidiaphragm
D. Over 500 lbs and/or a body circumference that prevents the study subject from laying flat in the scanner
E. Surgery of uncertain type
F. Untreatable claustrophobia otherwise requiring anesthesia.
G. Any that the Physician identifies from the subject, MRI Safety Questionnaire, and/or History and Physical.
EXCLUSION FOR PARTICIPANTS FOR GADOLINIUM CONTRAST:
(Inclusive of the above exclusion criteria):
A. Allergy to gadolinium for scans using contrast; will be eligible for non-contrast scans.
B. Acute renal failure, renal transplant, dialysis and renal failure individuals ( \<60 mL/min/1.73m2 and/or clinically diagnosed).
C. Individuals with a history of liver transplant or severe liver disease.
D. Lactating women
E. Individuals with hemoglobinopathies or severe asthma.
F. Patient preference to not undergo intravenous line placement and/or receive gadolinium contrast. Contrast administration is optional and participants may still undergo a non-contrast study.
G. GBCA with an MRI scan in the last 6 months. This includes scan performed with GBCA at any outside institution and / or at the clinical center .In addition, they cannot have reached their maximum of 4 GBCA imaging studies under this protocol. They will be excluded from having a contrast enhanced MRI, but will not be excluded from the protocol for non-contrast MRI studies.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Volunteers (maybe Volunteers, NIH employee and current NIH protocol participants)
To refine current methodology and develop new techniques for MRI
To refine current methodology and develop new techniques for magnetic resonance imaging in the general population.
Time frame: End of study
Plan to share: Undecided — We are working on deciding if we want to share IPD.
Started Jun 2010 (actual).
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
National Institutes of Health Clinical Center (CC) →