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CompletedNCT01102933REBUSUpdated Mar 26, 2014

RElevance of Biomarkers for Future Risk of Thromboembolic Events in UnSelected Post-myocardial Infarction Patients

An observational study in Myocardial Infarction, sponsored by Uppsala University. Completed at 1 site in Sweden. Per ClinicalTrials.gov, last updated 2014-03-26.

Sponsored by Uppsala University · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
425
Sex
All
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Study summary

The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410. The objectives are to:

Evaluate biomarkers and change of these related to myocardial infarction, during two years follow-up in an unselected patient population with a recent myocardial infarction.

Evaluate if an early change of biomarkers can be related to death, new myocardial infarction, and ischemic stroke in the same population after two and five years follow-up.

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Conditions studied

  • Myocardial Infarction
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In context

Myocardial Infarction

2,779 studies on the registry are indexed under Myocardial Infarction; 417 are open to participants now.

This study's enrollment of 425 is below the median of 500 across 999 observational studies indexed under Myocardial Infarction.

Browse Myocardial Infarction studies →

Lead sponsor

Uppsala University is the lead sponsor of 390 studies on the registry; 86 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients diagnosed wilth myocardial infarction and hospitalized at the Cardiology Department, Uppsala University Hospital, the study population will be unselected.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Myocardial infarction diagnosed by dynamic raised troponin I with at least one value above 0.1 µg/L. Together with at least one of the criteria; symptoms suggestive for myocardial infarction or development of significant Q wave.
  2. Treated at the Department of cardiology, Uppsala University Hospital.
  3. Ability to attend the scheduled visits for evaluation procedures.
  4. Signed Informed Consent.

Exclusion criteria

Exclusion Criteria:

  1. Death ≤ 5 days after the myocardial infarction.
  2. Not belonging to the catchment area of Uppsala University Hospital.
  3. Lack of suitability for participation in the trial, for any reason, as judged by the Investigator.
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
425 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Unselected post-myocard infarct patients

    Patients diagnosed with MI at Uppsala University Hospital

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What researchers measure

Primary outcomes

  1. Death, myocardial infarction, stroke

    Death: Death will be sub-classified by vascular or non-vascular primary cause. All deaths with unknown/uncertain cause will be categorized as vascular death. Myocardial Infarction(MI): Rehospitalization due to new non fatal MI or development of significant Q-wave. Stroke: Diagnosed as abrupt onset of focal neurological deficit persisting more than 24 hours.

    Time frame: Five years from study start

Secondary outcomes

  1. Venous thromboembolism, Arterial embolism, Bleeding

    Venous thromboembolism: Deep venous thrombosis has to be diagnosed by ultrasonography or venography. Pulmonary embolism has to be diagnosed by spiral CT scan, pulmonary angiogram or ventilation-perfusion scanning. Arterial embolism: Diagnosed as an arterial event. Radiological evidence includes imaging studies. Bleedings: Classified as major or minor using International Society on Thrombosis and Haemostasis (ISTH). Major bleeds will be diagnosed as fatal and/or symptomatic bleeding in critical area or organ and/or bleeding associated with a decrease in Hb of 20 g/L or more or leading to transfusion.

    Time frame: Five years from study start

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Study locations

1 site
  • Cardiology Department
    Uppsal University Hospital, Uppsala County 751 85, Sweden
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 26, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01102933
Lead sponsor
Uppsala University
Responsible party
Sponsor
First posted
Apr 13, 2010
Start date
Apr 2010
Primary completion
Aug 2012
Completion
Aug 2012
Last update
Mar 26, 2014

Study contacts

Christina Christersson, MD PhD
principal investigator · Cardiology Department, Uppsala University Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2014. You cannot join it, but the record below documents what was studied.

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