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CompletedNCT01074541Updated Feb 24, 2010

The Vitamin D Dose-Response Relationship

An interventional study of UVB and UVB in Vitamin D Status, sponsored by Bispebjerg Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-02-24.

Sponsored by Bispebjerg Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
55
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.

Read the detailed description

The work is addressing vitamin D production after UVB exposure and explore the importance of UVB dose and UV intensity. Four different UVB doses and four different UV intensities are used to explore these relationships.

Many assumptions have been made concerning the vitamin D production after UVB exposure but only few studies exist.

02

Conditions studied

  • Vitamin D Status

Keywords

  • Vitamin D
  • UVB
  • Dose-Response
  • UV intensity
  • Skin cancer
03

In context

Lead sponsor

Bispebjerg Hospital is the lead sponsor of 281 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • 18-65 years
  • Healthy

Exclusion criteria

Exclusion Criteria:

  • Sun bed use
  • Holiday or business travel south of 45 degrees latitude during trial
  • Illness
  • Drug addiction
  • Pregnancy
  • Lactating
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
55 participants (actual)

Study arms

  • Active comparator
    Group 1

    UV intensity 10 MIN

    Radiation: UVB

  • Active comparator
    Group 2

    UV intensity 5 MIN

    Radiation: UVB

  • Active comparator
    Group 3

    UV intensity 1 MIN

    Radiation: UVB

  • Active comparator
    Group 4

    UV intensity 20 MIN

    Radiation: UVB

Interventions

  • RadiationUVB

    0.375 SED x 4 in a week

    Also known as: UVB radiation

  • RadiationUVB

    0.75 SED x 4 in a week

    Also known as: UVB radiation

  • RadiationUVB

    1.5 SED x 4 in a week

    Also known as: UVB radiation

  • RadiationUVB

    3.0 SED x 4 in a week

    Also known as: UVB radiation

06

What researchers measure

Primary outcomes

  1. Vitamin D (nmol/l)

    Vitamin D measured in a blood sample to define the dose-response relationship between UVB dose, UV intensity and Vitamin D production in the skin after UVB exposure.

    Time frame: 2 days after exposure

Secondary outcomes

  1. Other parameters

    To invesitage whether other parameters like sex, BMI, Diet etc. influences the vitamin D production after UVB exposure.

    Time frame: 2 days after radiation

07

Study locations

1 site
  • Bispebjerg Hospital, Department of Dermatology
    Copenhagen NV, NV 2400, Denmark
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 24, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01074541
Lead sponsor
Bispebjerg Hospital
Collaborators
The Danish Medical Research Council
First posted
Feb 24, 2010
Start date
Jan 2008
Primary completion
Mar 2008
Completion
Feb 2010
Last update
Feb 24, 2010

Study contacts

Hans Christian Wulf, Professor
study chair · Bispebjerg Hospital, Deparment of Dermatology

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2010. You cannot join it, but the record below documents what was studied.

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