CClinicalTrials.gg
WithdrawnNCT01051947Updated Aug 1, 2011

Impact of Nebivolol on Central Aortic Pressure

An interventional study of Nebivolol and Metoprolol in Central Aortic Pressure, sponsored by Creighton University. Withdrawn at 1 site in United States. Open to participants aged 45 Years to 75 Years. Per ClinicalTrials.gov, last updated 2011-08-01.

Sponsored by Creighton University · Not applicable, Interventional, and Treatment

Why this study was withdrawn
Similar study already published
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
45 Years to 75 Years
Sex
All
01

Study summary

A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.

02

Conditions studied

  • Central Aortic Pressure

Keywords

  • Nebivolol
  • Metoprolol
  • central aortic pressure
  • hypertension
03

In context

Lead sponsor

Creighton University is the lead sponsor of 126 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Subjects with history of hypertension
  • Subjects who have received metoprolol for a minimum of 3 months

Exclusion criteria

Exclusion Criteria:

  • Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Investigator)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Nebivolol

    Nebivolol therapy for 2-6 weeks depending on blood pressure readings

    Drug: Nebivolol

  • Experimental
    Metoprolol

    Metoprolol therapy for 2-6 weeks depending on blood pressure readings

    Drug: Metoprolol

Interventions

  • DrugNebivolol

    10 mg by mouth daily for 2 weeks 20 mg by mouth daily for 2 weeks 40 mg by mouth daily for 2 weeks

  • DrugMetoprolol

    dosage prescribed prior to starting on study

06

What researchers measure

Primary outcomes

  1. Stable blood pressure

    Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.

    Time frame: 6 months

07

Study locations

1 site
  • The Cardiac Center at Creighton University
    Omaha, Nebraska 68131, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 1, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01051947
Lead sponsor
Creighton University
First posted
Jan 20, 2010
Start date
Dec 2009
Primary completion
May 2010
Completion
May 2010
Last update
Aug 1, 2011

Study contacts

Jennifer Campbell, PharmD
principal investigator · Creighton University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Jul 2011. You cannot join it, but the record below documents what was studied.

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