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CompletedNCT01035372Updated Mar 2, 2020

Pilot Study on the Tolerability of Dietary Dried Plum

An interventional study of dried plum powder in Healthy and Elderly, sponsored by University of California, San Francisco. Completed at 1 site in United States. Open to participants aged 50 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-03-02.

Sponsored by University of California, San Francisco · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
6
Allocation
Not applicable
Ages
50 Years to 75 Years
Sex
All
01

Study summary

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

02

Conditions studied

  • Healthy
  • Elderly

Keywords

  • healthy older people
03

In context

Lead sponsor

University of California, San Francisco is the lead sponsor of 2,132 studies on the registry; 375 are open to participants now.

Of its 262 completed or terminated interventional studies of FDA-regulated products, 196 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age between 50 yrs and 75 yrs
  • Nonsmokers
  • Normal renal and hepatic function

Exclusion criteria

Exclusion Criteria:

  • Subjects who must follow a specific diet
  • Subjects on any daily medications that affect bone health
  • Subjects too heavy for the DEXA machine (weight limit 300 lbs)
  • Subjects whose BMD by DEXA indicates osteoporosis
  • Subjects unwilling to follow the diet specified
  • Pregnant women
  • Subjects who are unable to understand the consent form.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
6 participants (actual)

Study arms

  • Experimental
    dried plum

    subjects will have 25% by weight (\~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder

    Dietary Supplement: dried plum powder

Interventions

  • Dietary supplementdried plum powder

    subjects will have 25% of their diet substituted by dried plum powder

06

What researchers measure

Primary outcomes

  1. urinary calcium excretion

    Time frame: one month

Secondary outcomes

  1. ability to tolerate the diet

    Time frame: one month

07

Study locations

1 site
  • University of California San Francisco
    San Francisco, California 94143, United States
08

References and documents

Publications

  • Deyhim F, Stoecker BJ, Brusewitz GH, Devareddy L, Arjmandi BH. Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause. 2005 Nov-Dec;12(6):755-62. doi: 10.1097/01.gme.0000185486.55758.5b. Epub 2005 Nov 8. PubMed 16278620 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 2, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01035372
Lead sponsor
University of California, San Francisco
Responsible party
Sponsor
First posted
Dec 18, 2009
Start date
Dec 2009
Primary completion
Sep 2010
Completion
Sep 2010
Last update
Mar 2, 2020

Study contacts

Bernard Halloran, MD
principal investigator · SFVAMC

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.

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