CClinicalTrials.gg
Sign In
CompletedNCT01034241Updated Aug 23, 2018

Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning

An interventional study of Control and High dairy protein in Insulin and Glucose Metabolism, sponsored by Maastricht University Medical Center. Completed. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-23.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Male
01

Study summary

The purpose of this study is to determine whether different protein diets affects glucose and insulin metabolism and substrate partitioning.

02

Conditions studied

  • Insulin
  • Glucose Metabolism

Keywords

  • milk protein
  • overweight
  • insulin metabolism
  • substrate partitioning
03

In context

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • BMI: 18.5-25 kg/m2 (lean)
  • Gender: Male
  • Age: \<35 years
  • Caucasian

Exclusion criteria

Exclusion Criteria:

  • Elevated fasting blood glucose level
  • Lactose intolerant
  • Diabetes Mellitus
  • Hypertension (systolic/diastolic blood pressure)
  • Hypotension (systolic/diastolic blood pressure)
  • Cardiovascular diseases
  • Asthma and other obstructive pulmonary diseases
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
12 participants (actual)

Study arms

  • Experimental
    Control

    Diet consists of 15% dairy protein and low Glycemic Index (GI \< 40), 55 En% carbohydrates and 30 En% fat

    Dietary Supplement: Control

  • Experimental
    High dairy protein

    Diet consists of 25% dairy protein and low GI (GI \< 40), 45 En% carbohydrates and 30 En% fat

    Dietary Supplement: High dairy protein

  • Experimental
    vegetable protein

    Diet consists of 15 En% vegetable protein and low GI (GI \< 40), 55 En% carbohydrates and 30 En% fat

    Dietary Supplement: vegetable protein

  • Experimental
    High GI

    Diet consists of 15 En% dairy protein and high GI(GI \> 60, 55 En% carbohydrates and 30 En% fat

    Dietary Supplement: High GI

Interventions

  • Dietary supplementControl

    Diet consists of 15 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat

  • Dietary supplementHigh dairy protein

    Diet consists of 25 En% dairy protein and low GI, 55 En% carbohydrates and 30 En% fat

  • Dietary supplementvegetable protein

    Diet consists of 15 En% vegetable protein and low GI, 55 En% carbohydrates and 30 En% fat

  • Dietary supplementHigh GI

    Diet consists of 15 En% dairy protein and high GI, 55 En% carbohydrates and 30 En% fat

06

What researchers measure

Primary outcomes

  1. Glucose and insulin metabolism (24 h)

    Time frame: 24 h

Secondary outcomes

  1. Substrate partitioning and metabolic markers

    Time frame: 24 h

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Munsters MJ, Geraedts MC, Saris WH. Effects of different protein and glycemic index diets on metabolic profiles and substrate partitioning in lean healthy males. Appl Physiol Nutr Metab. 2013 Nov;38(11):1107-14. doi: 10.1139/apnm-2012-0409. Epub 2013 Apr 25. PubMed 24053517 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 23, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01034241
Lead sponsor
Maastricht University Medical Center
Collaborators
Nederlandse Zuivel Organisatie
Responsible party
Sponsor
First posted
Dec 17, 2009
Start date
Apr 2009
Primary completion
Jan 2010
Completion
Mar 2010
Last update
Aug 23, 2018

Study contacts

Wim Saris, Prof. Dr.
principal investigator · Maastricht University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies from this sponsor

Maastricht University Medical Center

Start the discussion