An observational study in Osteoarthritis, Hip, sponsored by Stanford University. Status unknown at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-18.
Sponsored by Stanford University · Observational
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
628 studies on the registry are indexed under Osteoarthritis, Hip; 121 are open to participants now.
This study's planned enrollment of 50 is below the median of 141 across 154 observational studies indexed under Osteoarthritis, Hip.
Browse Osteoarthritis, Hip studies →Stanford University is the lead sponsor of 2,117 studies on the registry; 425 are open to participants now.
Of its 259 completed or terminated interventional studies of FDA-regulated products, 197 (76%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients scheduled for elective total hip arthroplasty through the Stanford Orthopedic Clinic.
Inclusion Criteria:- Adult (18 years of age or older)
Anesthetic Recovery Times
recovery from anesthesia will be measured by short-term outcomes like time to tracheal extubation and response to verbal commands, as well as by psycho-vigilance testing up to 72 hours postoperatively
Time frame: 0-72 hours after surgery
sensitivity to sevoflurane during inhalation induction to anesthesia, determined by bispectral index of the EEG
pharmacodynamic analysis of bispectral index of the EEG response to sevoflurane
Time frame: during anesthetic induction
pain and sleepiness
assessment of pain and sleepiness using the numerical rating scale (0-10) during the 72 hours postoperatively
Time frame: from 0-72 hours after surgery
This study is status unknown, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.
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Stanford University