An interventional study of Patients with a BMI < 30 given Oseltamivir and Patients with a BMI > 40 given Oseltamivir in Morbid Obesity, sponsored by IWK Health Centre. Completed at 1 site in Canada. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-08-03.
Sponsored by IWK Health Centre · Not applicable, Interventional, and Treatment
This trial asks the question: do people of much greater than average body weight need more of a drug called oseltamivir than current recommendations suggest. Oseltamivir is a drug given to people who have influenza, and currently is also being used to fight the new H1N1 influenza. Some people of larger than average body weight require larger amounts of drugs to see the same effects as others of an average body weight. No studies have ever been conducted looking at the possibility of oseltamivir being one of those drugs. Our Study's hypothesis states that those of an above average body weight will have different amounts of drug in their blood than those of people of normal body weight if they are given the normal amount prescribed for influenza. Our study will give oseltamivir to twenty people for 7 days. Half of the people will be of normal body weight and the others will be of a much higher than normal body weight. Using blood samples the investigators will determine if the amounts of oseltamivir are significantly lower in the blood of patients in the above normal body weight group.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 20 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
Browse Obesity studies →IWK Health Centre is the lead sponsor of 83 studies on the registry; 17 are open to participants now.
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Exclusion Criteria:
Adjusted body weight = Ideal body weight + [0.4 (Actual Bodyweight-Ideal Body Weight)]
Patients with a BMI \< 30 given Oseltamivir
Patients with a BMI \> 40 given Oseltamivir
Serum Drug Concentration
Time frame: 7 Days
This study is completed, as verified in Aug 2011. You cannot join it, but the record below documents what was studied.
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IWK Health Centre