An observational study in Hernia, sponsored by Herlev Hospital. Status unknown at 1 site in Denmark. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-10-13.
Sponsored by Herlev Hospital · Observational
Analysis of collagen subtype subcutaneously and genetic analysis of patients from families with a tendency to hernias. Furthermore circulating biomarkers and biomarkers extracted from the subcutaneously tissue such as MMP's (matrix metallo proteinases) and TIMP's (tissue inhibitor of metallo proteinases) will be measured.
Research has shown relationship between hernias and collagen subtype I/III ratio, biomarkers such as MMP's TIMP's and other diseases such as Ehlers-Danlos, Marfans syndrome, AAA (abdominal aortic aneurysms), diverticulosis and rectal prolapse. Furthermore has research raised hypothesis about inheritance of hernias. The investigators are performing genetic examination combined with analysis of collagen and biomarkers on patients belonging to families with tendency to hernias.
Other examinations performed on the patients enrolled in this study:
1,096 studies on the registry are indexed under Hernia; 132 are open to participants now.
This study's planned enrollment of 60 is below the median of 120 across 327 observational studies indexed under Hernia.
Browse Hernia studies →Herlev Hospital is the lead sponsor of 195 studies on the registry; 25 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients in Denmark operated or diagnosed with hernias who are member of a family with tendency to hernias.
Exclusion Criteria:
Expression of collagen-genes or other relevant genes by microarray analysis compared with presence of hernia
Time frame: 1 year
Amount of collagen subtypes measured subcutaneously.
Time frame: 1 year
This study is status unknown, as verified in Oct 2010. You cannot join it, but the record below documents what was studied.
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Herlev Hospital