CClinicalTrials.gg
CompletedNCT00991419Updated Jan 30, 2013

To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden

A Phase 2 interventional study of [18F]AZD4694 in Alzheimer's Disease, sponsored by AstraZeneca. Completed at 1 site in United States. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-01-30.

Sponsored by AstraZeneca · Phase 2, Interventional, and Diagnostic

Phase
Phase 2
Study type
Interventional
Enrollment
25
Allocation
Non-randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

The purpose of this study is to compare PET measurements of fibrillar amyloid burden using [18F]AZD4694.

02

Conditions studied

  • Alzheimer's Disease

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Keywords

  • PET
  • Alzheimer's disease
  • diagnostic
03

In context

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.

This study's enrollment of 25 is below the median of 70 across 2,808 interventional studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

AstraZeneca is the lead sponsor of 3,429 studies on the registry; 270 are open to participants now.

Of its 357 completed or terminated interventional studies of FDA-regulated products, 173 (48%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Male or female, of any race or/ethnicity
  • ECG, vital signs, and clinical laboratory values are within normal limits at enrollment or deemed not clinically significant by the physician

Exclusion criteria

Exclusion Criteria:

  • Significant recent (within 6 months) history of neurological (including stroke) or psychiatric disorder or substance abuse
  • Participated in a PET study within the last 12 months
  • Pregnancy or lactation
05

Study design

Phase
Phase 2
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
25 participants (actual)

Study arms

  • Experimental
    A

    \[18F\]4694

    Drug: [18F]AZD4694

Interventions

  • Drug[18F]AZD4694

    \[18F\]AZD4694 PET Ligand administered at Visit 1, 30 days following screening and at visit 4 for some of the participants.

06

What researchers measure

Primary outcomes

  1. PET Measurements

    Time frame: Day 1 and Day 7

07

Study locations

1 site
  • Research Site
    Phoenix, Arizona, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 30, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00991419
Lead sponsor
AstraZeneca
Responsible party
Sponsor
First posted
Oct 8, 2009
Start date
Feb 2010
Primary completion
Aug 2011
Completion
Aug 2011
Last update
Jan 30, 2013

Study contacts

Eric M Reiman, MD
principal investigator · Banner Alzheimer's Institute

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.

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