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CompletedNCT00976196PHPUpdated Dec 2, 2015

Platelet Hyperreactivity Project

An observational study in Platelet Reactivity, sponsored by Pierre Fontana. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2015-12-02.

Sponsored by Pierre Fontana · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
110
Ages
18 Years to 99 Years
Sex
All
01

Study summary

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.

Read the detailed description

The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype.

Main objective:

  • to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

Secondary objectives:

  • to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
  • to determine genetic polymorphisms associated with platelet hyperreactivity
02

Conditions studied

  • Platelet Reactivity

Keywords

  • Aspirin
  • Blood platelets
  • proteomics
  • Platelet reactivity
03

In context

Lead sponsor

Pierre Fontana is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 99 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Symptomatic atherothrombotic patients treated with aspirin.

Inclusion criteria

  • Documented symptomatic ischemic atherothrombotic disease treated by aspirin.

Exclusion criteria

Exclusion Criteria:

  • Known platelet disorder
  • Chronic treatment by antiplatelet drugs other than aspirin
  • Chronic anticoagulant treatment
  • Chronic non steroidal anti-inflammatory drug treatment
  • Active cancer
  • Treatment with serotonin reuptake inhibitors
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
110 participants (actual)
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. proteome profile of platelet hyperreactivity

    to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients

    Time frame: cross sectional

Secondary outcomes

  1. platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin

    Time frame: cross sectional

Other outcomes

  1. genetic polymorphisms associated with platelet hyperreactivity

    Time frame: cross sectional

07

Study locations

1 site
  • University Hospital Geneva
    Geneva, 1205, Switzerland
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 2, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00976196
Lead sponsor
Pierre Fontana
Responsible party
Pierre Fontana (PI, University Hospital, Geneva) — Sponsor-investigator
First posted
Sep 14, 2009
Start date
Jan 2009
Primary completion
Jan 2010
Completion
Jan 2010
Last update
Dec 2, 2015

Study contacts

Pierre Fontana, MD, PhD
principal investigator · University of Geneva

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.

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