CClinicalTrials.gg
CompletedNCT00975390Updated Apr 14, 2015

Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates

An interventional study of Carbohydrate and Carbohydrate and protein ingestion in Exercise Recovery, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-14.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
14
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Male
01

Study summary

The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes.

The investigators hypothesize that both interventions (the addition of caffeine or protein+leucine) will lead to higher glycogen re-synthesis compared to the ingestion of CHO only, and that the co-ingestion of protein and leucine will result in the highest muscle glycogen synthesis rates.

02

Conditions studied

  • Exercise Recovery

Keywords

  • Glycogen
  • Carbohydrate
  • Protein
  • Caffeine
  • Post exercise muscle glycogen synthesis
  • Sports nutrition
03

In context

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • male cyclists
  • healthy
  • BMI \< 25

Exclusion criteria

Exclusion Criteria:

  • female
  • use of medication
  • non cycling
  • BMI > 25
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
14 participants (actual)

Study arms

  • Experimental
    1

    Carbohydrate ingestion

    Dietary Supplement: Carbohydrate

  • Experimental
    2

    Carbohydrate and protein ingestion

    Dietary Supplement: Carbohydrate and protein ingestion

  • Experimental
    3

    Carbohydrate and caffeine ingestion

    Dietary Supplement: Carbohydrate and caffeine ingestion

Interventions

  • Dietary supplementCarbohydrate

    1.2 g/kg/h

  • Dietary supplementCarbohydrate and protein ingestion

    1.2 g/kg/h carbohydrate plus 0.4 g/kg/h protein

  • Dietary supplementCarbohydrate and caffeine ingestion

    1.2 g/kg/h carbohydrate and 1.67 g/kg/h caffeine

06

What researchers measure

Primary outcomes

  1. Muscle glycogen synthesis rates

    Time frame: 6 hours

Secondary outcomes

  1. Glycogen synthase activity, plasma glucose, insulin, free fatty acids and epinephrine responses

    Time frame: 6 hours

07

Study locations

1 site
  • Maastricht University
    Maastricht, Netherlands
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 14, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00975390
Lead sponsor
Maastricht University Medical Center
Responsible party
Milou Beelen (Dr., Maastricht University Medical Center) — Principal investigator
First posted
Sep 11, 2009
Start date
Feb 2009
Primary completion
Sep 2009
Completion
Sep 2009
Last update
Apr 14, 2015

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2015. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion