An observational study in Sickle Cell Anemia and Thalassemia, sponsored by HaEmek Medical Center, Israel. Completed at 1 site in Israel. Open to participants aged 1 Year to 35 Years. Per ClinicalTrials.gov, last updated 2011-08-26.
Sponsored by HaEmek Medical Center, Israel · Observational
The spleen in Sickle Cell Anemia and Sickle Cell Thalassemia is usually enlarged in the first years of life but the immune protection provided is considered insufficient. In homozygous Sickle cell patients the spleen usually developed recurrent infarcts and after the first decade of age become fibrotic. Acute splenic sequestration is also frequent in those patients and this is considered as an indication for splenectomy.
In comparison in Sickle cell thalassemia patients, hypersplenism is more frequent.
The purpose of this study is to compare the clinical and laboratory issues related to the spleen in two groups of Sickle cell patients.
Clinical and laboratory characteristics related to the spleen in SCA patients will be studied.
Two groups of patient will be compared, a group of Sickle cell patients (Homozygous) and a second group of patients with Sickle cell beta thalassemia.
In those patients that splenectomy was performed the incidence of infections will be recorded besides the indications for splenectomy and the incidence of thrombotic events or thrombocytosis.
1,733 studies on the registry are indexed under Anemia; 246 are open to participants now.
This study's planned enrollment of 50 is below the median of 200 across 326 observational studies indexed under Anemia.
Browse Anemia studies →HaEmek Medical Center, Israel is the lead sponsor of 228 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Two groups of patients: 25 patients with homozygous Sickle Cell Anemia and 25 patients with Sickle Cell Thalassemia
Exclusion Criteria:
Patients with homozygous Sickle Cell Anemia
Patients with Sickle Cell Thalassemia
Clinical events and abnormal laboratory results
Time frame: One year
This study is completed, as verified in Aug 2011. You cannot join it, but the record below documents what was studied.
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HaEmek Medical Center, Israel