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CompletedNCT00931437Updated Dec 16, 2010

Vitamin K-absorption From Dairy

An interventional study of vitamin K-rich dairy product in Healthy, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-12-16.

Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Not applicable
Ages
20 Years to 45 Years
Sex
All
01

Study summary

Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.

02

Conditions studied

  • Healthy

Keywords

  • vitamin K
  • Bio-availability
03

In context

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 852 studies on the registry; 116 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Healthy men and women between 20 and 45 years old
  • Subjects of normal body weight and height according to BMI \< 30
  • Subjects of Caucasian race
  • Subject has given written consent to take part in the study

Exclusion criteria

Exclusion Criteria:

  • Subjects with (a history of) metabolic or gastrointestinal disease
  • Subjects presenting chronic degenerative and/or inflammatory disease
  • Abuse of drugs and/or alcohol
  • Subjects receiving corticoid treatment
  • Subjects using oral anticoagulants
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
12 participants (actual)

Study arms

  • Experimental
    vitamin K-rich dairy product

    one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.

    Dietary Supplement: vitamin K-rich dairy product

Interventions

  • Dietary supplementvitamin K-rich dairy product

    several forms of vitamin K: phylloquinone, menaquinone-7,-8,-9,and -10.

06

What researchers measure

Primary outcomes

  1. serum vitamin K levels: phylloquinone, menaquinone-7,-8,-9,and -10

    Time frame: one single intake

Secondary outcomes

  1. distribution of vitamin K-forms over lipoprotein fractions: triglyceride rich lipoprotein (TGRLP), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), high density lipoprotein (HDL) as well as the lipoprotein-free fraction (LPF)

    Time frame: one single intake

07

Study locations

1 site
  • VitaK BV / University of Maastricht
    Maastricht, Netherlands
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 16, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00931437
First posted
Jul 2, 2009
Start date
Apr 2009
Primary completion
Jul 2009
Completion
Nov 2009
Last update
Dec 16, 2010

Study contacts

Cees Vermeer, PhD
principal investigator · VitaK / University of Maastricht

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2010. You cannot join it, but the record below documents what was studied.

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