An interventional study of secondhand smoke exposure in Endothelial Function and Platelet Aggregation, sponsored by Kantonsspital Graubünden. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-08-11.
Sponsored by Kantonsspital Graubünden · Not applicable, Interventional, and Prevention
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.
Kantonsspital Graubünden is the lead sponsor of 4 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.
Change in platelet aggregation and/or endothelial function
Time frame: 12-24 hours
This study is completed, as verified in Aug 2009. You cannot join it, but the record below documents what was studied.
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Kantonsspital Graubünden