An observational study in Healthy, no Evidence of Disease and Lung Cancer, sponsored by Vanderbilt-Ingram Cancer Center. Completed at 3 sites in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-06-24.
Sponsored by Vanderbilt-Ingram Cancer Center · Observational
RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer.
PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.
OBJECTIVES:
OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.
7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.
This study's enrollment of 37 is below the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →Vanderbilt-Ingram Cancer Center is the lead sponsor of 220 studies on the registry; 32 are open to participants now.
Of its 23 completed or terminated interventional studies of FDA-regulated products, 18 (78%) have results posted.
Counted across the registry records on this site, refreshed daily.
Healthy, non-smokers.
DISEASE CHARACTERISTICS:
Healthy participant
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Genetic: proteomic profiling · Other: biologic sample preservation procedure · Other: laboratory biomarker analysis · Procedure: bronchoscopy
Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath
Collection of breath condensate.
Collection of biological specimens to use as controls in the study of lung cancer progression
Specimens are collected from healthy participants with no known risk of lung cancer
Time frame: Off study date, up to one year
Identification of new molecular abnormalities specific to the development of squamous cell carcinoma of the lung
Time frame: off-study date, up to one year
Selection of important genes/proteins differentially expressed between study groups (e.g., normal vs low-grade vs high-grade vs invasive) and between normal smokers vs normal non-smokers
Time frame: off-study date, up to one year
This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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Vanderbilt-Ingram Cancer Center