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CompletedNCT00885300Updated Apr 21, 2009

Cloxacillin as Prevention of Double Lumen Infection in Hemodialysis Patients

An interventional study of cloxacillin and heparin in Double Lumen Infection and Hemodialysis, sponsored by Shiraz University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-04-21.

Sponsored by Shiraz University of Medical Sciences · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The purpose of this study is to investigate whether cloxacillin lock is effective in prevention of double lumen infection.

Read the detailed description

Double lumen infection is one of the causes of morbidity and mortality in hemodialysis patients. Many strategies used to prevent it and one of them is antibiotic lock. Thus we select chronic hemodialysis patients and divided them into 2 groups. One group received cloxacillin and heparin as catheter lock and the second group received only heparin lock.

02

Conditions studied

  • Double Lumen Infection
  • Hemodialysis
03

In context

Infections

6,687 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 100 is below the median of 120 across 4,200 interventional studies indexed under Infections.

Browse Infections studies →

Lead sponsor

Shiraz University of Medical Sciences is the lead sponsor of 129 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • hemodialysis for 3 months
  • at least 2 time dialysis/week

Exclusion criteria

Exclusion Criteria:

  • active infection
  • acute renal failure
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
100 participants (actual)

Study arms

  • Experimental
    1

    cloxacillin 100 mg/ml + heparin 1000iu/ml as catheter lock at the end of hemodialysis

    Drug: cloxacillin · Drug: heparin

  • Active comparator
    2

    heparin 1000iu/ml as catheter lock at the end of hemodialysis

    Drug: heparin

Interventions

  • Drugcloxacillin

    cloxacillin 100mg/ml as catheter lock at the end of hemodialysis

  • Drugheparin

    heparin 1000iu/ml as catheter lock at the end of hemodialysis

06

What researchers measure

Primary outcomes

  1. catheter infection

    Time frame: 6 months

07

Study locations

1 site
  • Shiraz University Hemodialysis Center
    Shiraz, Fars o98-711, Iran, Islamic Republic of
08

References and documents

Publications

  • Unver S, Atasoyu EM, Evrenkaya TR, Ardic N, Ozyurt M. Risk factors for the infections caused by temporary double-lumen hemodialysis catheters. Arch Med Res. 2006 Apr;37(3):348-52. doi: 10.1016/j.arcmed.2005.07.010. PubMed 16513483 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 21, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00885300
Lead sponsor
Shiraz University of Medical Sciences
First posted
Apr 21, 2009
Start date
Jan 2008
Primary completion
Jul 2008
Completion
Sep 2008
Last update
Apr 21, 2009

Study contacts

maryam pakfetart, assistant professor
study chair · Shiraz nephro-urology research center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2009. You cannot join it, but the record below documents what was studied.

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