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Status unknownNCT00866151Updated Mar 20, 2009

A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs

An observational study in Weight Management, Diet Conditions and Dietary Recommendations, sponsored by Interleukin Genetics, Inc.. Status unknown at 1 site in United States. Open to female participants aged 25 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-03-20.

Sponsored by Interleukin Genetics, Inc. · Observational

The sponsor has not verified this record recently (last verified Mar 2009), so the status shown — last known as Enrolling by invitation — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
150
Ages
25 Years to 50 Years
Sex
Female
01

Study summary

The goal of this study is to determine the association between genotypes and diet. The weight and weight loss data are already available from the previously completed study called: A to Z Study - Benefits and Risks of Alternative Weight Loss Strategies - A Clinical Trial, which was performed from 2003-2005 at Stanford University. In the present study, Interleukin Genetics will obtain DNA samples from the previously enrolled study subjects to investigate genetic influence of the response to macronutrient compositions of low caloric diets to weight loss.

Read the detailed description

Interleukin Genetics has derived, through an extensive search of the scientific literature, a genetic test panel in the area of Weight Management (WM), which includes the genes that have been shown to affect body weight. These genes have been associated with elevated risk for obesity.

02

Conditions studied

  • Weight Management
  • Diet Conditions
  • Dietary Recommendations
  • Overweight Management
  • Obesity

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Keywords

  • genetic biomarker
  • biomarker
  • molecular diagnostics
  • genes
  • genetics
  • overweight management
  • weight management
  • weight reduction
  • SNPs
  • single nucleotide polymorphisms
03

In context

Overweight

3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.

This study's planned enrollment of 150 is close to the median of 150 across 436 observational studies indexed under Overweight.

Browse Overweight studies →

Lead sponsor

Interleukin Genetics, Inc. is the lead sponsor of 5 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
25 Years to 50 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

The study population for the A to Z study are premenopausal women who are overweight (BMI 27-40 kg/m2) but in otherwise good general health. Overweight participants with potentially confounding health conditions are excluded (eg., hypertension, diabetes, heart disease, cancer). Children were not included in this study. The participants were asked to agree to a random assignment to dietary plans.

Inclusion criteria

  • BMI (body mass index): 27-40 kg/m2
  • Gender: Women only
  • Age: 25-50
  • Menopausal status: pre-menopausal
  • Weight stable for last 2-months
  • Not on a weight loss plan
  • No ethnic restrictions
  • No plans to move from the area over the next 6-months
  • Willing to accept random assignment
  • Possess English speaking and reading skills to understand and complete forms such as informed consent and study evaluation

Exclusion criteria

Exclusion Criteria:

  • Hypertension
  • Diabetes (type 1 or 2) or history of gestational diabetes
  • Heart disease diagnosis
  • Renal or lever disease
  • Active neoplasms
  • Pregnant, lactating, within 6-months of birth, or planning to become pregnant in the next 6-months
  • Hyperthyroidism, unless treated and under control
  • Medications known to affect weight / energy expenditure
  • Excessive alcohol intake (self-reported, > 3 drinks/day)
  • Postmenopausal, including surgical menopause
  • Currently under psychiatric care, or severely clinically depressed (>17 on Beck Inventory)
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
150 participants (estimated)
Biospecimen retention
Samples with dna

Groups and cohorts

  • 1

    Previously enrolled subjects in the "Benefits and Risks of Alternative Weight Loss Strategies - a Clinical Trial", which was run at Stanford 2003-2005. (A to Z Study)

06

What researchers measure

Primary outcomes

  1. The PRIMARY objective of this study is to identify genotype-diet interaction on weight, body fat, and BMI.

    Time frame: 1 year

Secondary outcomes

  1. The SECONDARY objective is to explore the association of single nucleotide polymorphisms (SNPs) with other metabolic parameters, such as blood lipid profile, insulin level, and other cardiovascular risk factors.

    Time frame: 1 year

07

Study locations

1 site
  • Stanford University
    Stanford, California 94305-5401, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 20, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00866151
Lead sponsor
Interleukin Genetics, Inc.
First posted
Mar 20, 2009
Start date
Aug 2008
Primary completion
Jun 2009 (estimated)
Completion
Sep 2009 (estimated)
Last update
Mar 20, 2009

Study contacts

Christopher Gardner, PhD
principal investigator · Stanford University

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2009. You cannot join it, but the record below documents what was studied.

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