An interventional study of Multidisciplinary drug reviews by pharmacist and physician in Anticholinergic Side Effects, sponsored by Ullevaal University Hospital. Completed at 1 site in Norway. Per ClinicalTrials.gov, last updated 2015-06-19.
Sponsored by Ullevaal University Hospital · Not applicable, Interventional, and Prevention
Thesis: Is drug-induced anticholinergic activity additive resulting in a total anticholinergic load causing harmful side effects in old, fragile patients? Is it possible to reduce the anticholinergic load by multidisciplinary medical review including a pharmacist and a physician? The effects of the medical reviews are measured by cognitive tests (MMS and CERADS word lists), a measure of mouth dryness, serum levels of anticholinergic activity, activity of daily living and neuropsychiatric symptoms.
Design: A randomized, controlled, single blinded interventional study in Norwegian nursing homes.
Several studies have claimed that drugs showing anticholinergic activity in vitro cause high levels of serum anticholinergic activity in vivo that might cause impaired cognitive and functional functions in elderly. Pathophysiological changes in Alzheimer's dementia makes these patients particularly vulnerable for anticholinergic cognitive impairments. The PRADA-study is the first interventional study evaluating the clinical effects of reducing drug-induced anticholinergic load in patients with dementia. This is also the first interventional study in the Nordic countries evaluating the clinical effects of clinical pharmacy.
Ullevaal University Hospital is the lead sponsor of 76 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Reduction of anticholinergic drug effects by pharmacist review
Other: Multidisciplinary drug reviews by pharmacist and physician
No intervention
Reduction of anticholinergic drug effects by pharmacist review
CERADS word list measuring immediately and delayed recall
Time frame: 4 years
Mouth dryness
Time frame: 4 years
ADL
Time frame: 4 years
Serum anticholinergic activity
Time frame: 4 years
CERADS word list recognition
Time frame: 4 years
MMSE
Time frame: 4 years
NPI
Time frame: 4 years
This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.
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Ullevaal University Hospital