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CompletedNCT00840723SCCOR BronchUpdated Sep 5, 2013

Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects

An observational study in Respiratory Diseases, sponsored by University of North Carolina, Chapel Hill. Completed at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-09-05.

Sponsored by University of North Carolina, Chapel Hill · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
30
Ages
18 Years to 75 Years
Sex
All
01

Study summary

The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers. These samples will be used for test-tube studies to explore mechanisms of diseases of the respiratory tract, and to compare the samples between people who smoke cigarettes and people who don't. Obtaining these samples requires an invasive procedure called "bronchoscopy".

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Conditions studied

  • Respiratory Diseases

Keywords

  • Healthy smokers
  • Current cigarette smokers
  • No lung disease
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In context

Respiratory Tract Diseases

617 studies on the registry are indexed under Respiratory Tract Diseases; 111 are open to participants now.

This study's enrollment of 30 is below the median of 294 across 216 observational studies indexed under Respiratory Tract Diseases.

Browse Respiratory Tract Diseases studies →

Lead sponsor

University of North Carolina, Chapel Hill is the lead sponsor of 1,340 studies on the registry; 133 are open to participants now.

Of its 155 completed or terminated interventional studies of FDA-regulated products, 136 (88%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Current cigarette smokers who are otherwise healthy (no lung disease or other chronic illness and healthy controls

Inclusion criteria

  • Current cigarette smokers
  • Must be otherwise healthy with no chronic illness

Exclusion criteria

Exclusion Criteria:

  • Asthma
  • Smoking related lung disease (including bronchitis)
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Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
30 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Current smokers

    Current cigarette smokers with no other illness

  • Healthy controls

    Healthy non smokers

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What researchers measure

Primary outcomes

  1. The goal of this project is to define the effect of smoking on key aspects of airway biology. These studies will also provide crucial & novel definition of airway biology in smokers against which COPD & CF patients will be compared.

    Time frame: At the time of bronchoscopy

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Study locations

1 site
  • UNC Center for Environmental Medicine, Asthma and Lung Biology
    Chapel Hill, North Carolina 27599, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 5, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00840723
Lead sponsor
University of North Carolina, Chapel Hill
Responsible party
Raymond Coakley, MD (Assistant Professor of Medicine, University of North Carolina, Chapel Hill) — Principal investigator
First posted
Feb 10, 2009
Start date
Feb 2009
Primary completion
Aug 2013
Completion
Aug 2013
Last update
Sep 5, 2013

Study contacts

Raymond Coakley, MD
principal investigator · University of North Carolina

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2013. You cannot join it, but the record below documents what was studied.

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