CClinicalTrials.gg
CompletedNCT00832663Updated Mar 16, 2010

Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

An interventional study of NSAID and placebo in Muscle Damage, sponsored by Bispebjerg Hospital. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-03-16.

Sponsored by Bispebjerg Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
Male
01

Study summary

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Read the detailed description

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

02

Conditions studied

  • Muscle Damage

Keywords

  • Muscle regeneration
  • Satellite cells
  • electrical stimulation
  • eccentric contractions
  • myogenic precursor cells
03

In context

Lead sponsor

Bispebjerg Hospital is the lead sponsor of 281 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • male
  • healthy
  • does not exercise regularly

Exclusion criteria

Exclusion Criteria:

  • displays contraindications for taking NSAID
  • well-trained
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
32 participants (actual)

Study arms

  • Experimental
    NSAID

    receive NSAID

    Drug: NSAID

  • Placebo comparator
    Placebo

    receive placebo

    Drug: placebo

Interventions

  • DrugNSAID

    Effect of NSAID ingestion on muscle regeneration

  • Drugplacebo

    receive placebo

06

What researchers measure

Primary outcomes

  1. Muscle regeneration

    Time frame: 1 month

Secondary outcomes

  1. Muscle strength

    Time frame: 1 month

07

Study locations

1 site
  • Bispebjerg Hospital
    Copenhagen, NV 2400, Denmark
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 16, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00832663
Lead sponsor
Bispebjerg Hospital
Collaborators
Lundbeck Foundation, Team Denmark, Danish Ministry of Culture, Anti Doping Danmark, The Danish Rheumatism Association, King Christian IX and Queen Louise Jubilee Bursary
First posted
Jan 30, 2009
Start date
Apr 2009
Primary completion
Dec 2009
Completion
Dec 2009
Last update
Mar 16, 2010

Study contacts

Abigail L Mackey, PhD
principal investigator · Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.

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