An observational study in Chest Pain and Ischemia, sponsored by Stanford University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-05.
Sponsored by Stanford University · Observational
Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.
This is a prospective registry of patients with chest pain, chest discomfort, breathlessness who do not have a blockage in their heart artery. This condition is known as angina/ischemia and non-obstructive coronary arteries (ANOCA/INOCA). The purpose of this registry is to help us understand the prevalence, causes of these conditions, identify effective diagnostic strategy, and long term outcome in this patient population.
Patients will undergo comprehensive invasive evaluation including coronary angiography, intravascular imaging, and physiologic measurements as a standard of care. Details regarding the participant's angiogram, endothelial function testing, microvascular testing, intravascular ultrasound, and myocardial bridge testing, if performed, will be entered into a research database.
Participants may be contacted by email or phone periodically for follow-up information, such as surveys, an update on medical history, and/or a check on their medical status or symptoms. We anticipate gathering these data at 6 months, 1 year, 3 years, 5 years, and 10 years, and every 5 years thereafter following their enrollment.
The overall objective of this registry study is to identify specific endotypes of ANOCA by invasive evaluation and study long term outcome.
Specific goals include:
381 studies on the registry are indexed under Chest Pain; 66 are open to participants now.
This study's planned enrollment of 2,000 is above the median of 500 across 163 observational studies indexed under Chest Pain.
Browse Chest Pain studies →Stanford University is the lead sponsor of 2,117 studies on the registry; 425 are open to participants now.
Of its 259 completed or terminated interventional studies of FDA-regulated products, 197 (76%) have results posted.
Counted across the registry records on this site, refreshed daily.
Adult women and men with angina who have been referred for an elective coronary angiogram because of a reasonable clinical suspicion of coronary ischemia.
Exclusion Criteria:
Sex Differences in Endothelial Dysfunction, Microvascular Dysfunction, and Diffuse Plaque
This outcome is to measure the prevalence of angina and non-obstructive coronary arteries (ANOCA) endotypes
Time frame: Day of procedure (study day one)
Number of participants with major adverse cardiovascular events (MACE)
MACE - death, heart attack, revascularization, stroke
Time frame: 15 years
Change in Seattle angina questionnaire score
Scores range from 0 - 100, higher score means better outcome
Time frame: Baseline, 6 months, 1 year, 3 year, every 5 years thereafter
Number of patients with cardiovascular rehospitalization
Time frame: 15 years
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Stanford University