An interventional study of exposure to heat in "Exposure to Heat", sponsored by Prof. Yoram Epstein. Terminated at 1 site in Israel. Open to male participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-12-19.
Sponsored by Prof. Yoram Epstein · Not applicable, Interventional, and Basic science
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.
This is the only study on the registry with Prof. Yoram Epstein as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: exposure to heat
Dressed in shorts and tennis shoes the subjects will be exposed to exercise-heat stress for 12 consecutive days (excluding Saturday). Daily exposure will last 120 min, under the controlled environmental conditions of 40oC and 40% relative humidity. The exercise will consist of walking on a treadmill at a pace of 5km/h and 2% incline.
Also known as: acclimation to heat
Investigating the variability in the levels of different cytokine and the kinetics in cytokine levels during the process of acclimation to heat.
Time frame: 12 days
This study is terminated, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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