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CompletedNCT00802009Updated Jan 26, 2010

Dexamethasone and Analgesic Duration After Supraclavicular Brachial Plexus Blockade

An interventional study of Dexamethasone and Mepivicaine in Anesthesia, sponsored by University Health Network, Toronto. Completed at 1 site in Canada. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2010-01-26.

Sponsored by University Health Network, Toronto · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
44
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

Patients undergoing surgery of the hand often are treated with a nerve block in the shoulder/neck area that provides anesthesia/numbing during surgery. Nerve blocks usually last for a few hours after surgery and provide pain relief for this period. It may be possible to extend the duration of anesthesia by using a steroid, which has anti-inflammtory properties. This study will compare the duration of the nerve block when dexamethasone (steroid) is added to the anesthetic injected around the nerve.

02

Conditions studied

  • Anesthesia

Keywords

  • ultrasound-guided regional anesthesia
  • nerve block
  • brachial plexus
  • mepivicaine
  • dexamethasone
  • hand wrist surgery
  • duration
  • anesthetic duration following brachial plexus/nerve block for hand/wrist surgery
03

In context

Lead sponsor

University Health Network, Toronto is the lead sponsor of 1,411 studies on the registry; 292 are open to participants now.

Of its 17 completed or terminated interventional studies of FDA-regulated products, 3 (18%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Patients having unilateral hand or forearm surgery under Supraclavicular brachial plexus blockade.
  2. ASA I-III
  3. Age 18-60
  4. BMI \< 35

Exclusion criteria

Exclusion Criteria:

  1. Patients with a known history of hypersensitivity to local anesthetics and dexamethasone.
  2. Contra-indication to regional anesthesia/ supraclavicular brachial plexus blockade e.g. bleeding diathesis, coagulopathy.
  3. Peripheral neuropathy.
  4. Peptic ulcer disease.
  5. Diabetes Mellitus.
  6. Inability to give informed consent.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
44 participants (estimated)

Study arms

  • Experimental
    1

    Dexamethasone 8mg added to routine local anesthetic during brachial plexus blockade.

    Drug: Dexamethasone · Drug: Mepivicaine

  • Active comparator
    2

    Routine anesthetic solution (30 cc 1.5% mepivicaine) used during brachial plexus blockade.

    Drug: Mepivicaine

Interventions

  • DrugDexamethasone

    Dexamethasone 8 milligrams (liquid) will be added to standard anesthetic solution administered during routine brachial plexus nerve blockade.

  • DrugMepivicaine

    Standard anesthetic solution administered during routine brachial plexus nerve blockade.

06

What researchers measure

Primary outcomes

  1. Duration of anesthesia

    Time frame: hourly for first 24 hours; daily until discharge

Secondary outcomes

  1. Requirements for pain medications; complications

    Time frame: up to 3 months

07

Study locations

1 site
  • Toronto Western Hospital, University Health Network
    Toronto, Ontario M6G 2N6, Canada
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 26, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00802009
Lead sponsor
University Health Network, Toronto
First posted
Dec 4, 2008
Start date
May 2009
Primary completion
Oct 2009
Completion
Nov 2009
Last update
Jan 26, 2010

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2010. You cannot join it, but the record below documents what was studied.

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