An interventional study of Randomized application of intraoperative tidal volume and Randomized application of intraoperative tidal volume in Pulmonary Function, sponsored by Heinrich-Heine University, Duesseldorf. Completed at 1 site in Germany. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2010-09-24.
Sponsored by Heinrich-Heine University, Duesseldorf · Not applicable, Interventional, and Prevention
Lung function impairment is common after abdominal surgery. Few preventive strategies exist against postoperative lung function impairment. A new potential preventive strategy against postoperative lung function impairment comes from research on critically ill patients with severe respiratory failure. In this field research has long focused on influence of breathing volume (= tidal volume) during mechanical ventilation on outcome. It has been shown, that low tidal volumes improve patients outcomes as compared to (conventional) high tidal volumes. Therefore, we propose a patient and investigator blinded randomised trial to test the hypotheses that intraoperative mechanical ventilation with low tidal volumes as compared to high tidal volumes reduces postoperative lung function impairment in high risk patients.
Heinrich-Heine University, Duesseldorf is the lead sponsor of 174 studies on the registry; 52 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
intraoperative mechanical ventilation with 6 ml/kg predicted body weight
Other: Randomized application of intraoperative tidal volume
intraoperative mechanical ventilation with 12 ml/kg predicted body weight
Other: Randomized application of intraoperative tidal volume
intraoperative mechanical ventilation with 6 ml/kg predicted body weight
Also known as: Respiratory management
intraoperative mechanical ventilation with 12 ml/kg predicted body weight
Also known as: Respiratory management
Lung function as assessed by spirometry
Time frame: 1 year
lung function as assessed by blood gas analysis
Time frame: 1 year
time till hospital discharge
Time frame: 1 year
postoperative organ dysfunction
Time frame: 1 year
postoperative chest x-rays
Time frame: 1 year
time till mobilisation
Time frame: 1 year
This study is completed, as verified in Sep 2010. You cannot join it, but the record below documents what was studied.
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Heinrich-Heine University, Duesseldorf