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WithdrawnNCT00786578Updated Oct 24, 2014

Evaluation of Skeletal Muscle Lipid Content by Magnetic Resonance Spectroscopy

An observational study in Healthy, sponsored by University of Minnesota. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-10-24.

Sponsored by University of Minnesota · Observational

Why this study was withdrawn
not funded
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
0
Ages
18 Years to 45 Years
Sex
All
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Study summary

Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well. The skeletal muscle is one of the largest users of sugar in the body, when the skeletal muscle is "insulin resistant", this contributes to diabetes. There is some evidence that the amount of fat in the skeletal muscle is related to the amount of insulin resistance. We are asking people to participate in a study to look at the amount of fat in muscle and how this fat amount changes with exercise. We hypothesize that heavier people will have higher amounts of fat and deplete this fat more slowly than lean subjects.

Read the detailed description

High intramyocellular lipid (IMCL) content in skeletal muscle has been correlated to insulin resistance in obese subjects. Yet, endurance athletes have high intramyocellular lipid content and very low insulin resistance. There are several explanations for this paradox. This study will use a new magnetic resonance imaging technique to look at the amount of fat in the muscle and its depletion with exercise. We hypothesize that overweight subjects will have higher amounts of fat and deplete this fat more slowly than lean subjects.

02

Conditions studied

  • Healthy

Keywords

  • training
  • intramyocellular lipid
  • insulin resistance
03

In context

Lead sponsor

University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.

Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy subjects on regular running program.

Inclusion criteria

  • Age range will be from age 18 to 45. We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
  • We will define the lean trained group by a BMI of \< 24 kg/m2. We will define the overweight group as BMI > 26 25 kg/m2.
  • The subjects should be participating in regular running exercise (> 30 min/day, ≥ 5 days/week).
  • Weight must be stable [+/- 5 pounds] for at least the three months prior to the study for all participants.

Exclusion criteria

Exclusion Criteria:

  • The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
  • The subjects should not be on a high fat diet (> 45% fat) as measured by a screening questionnaire.
  • The subject must not have any contraindications to magnetic resonance imaging.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
0 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • 1

    overweight runners (BMI\>25)

  • 2

    lean runners (BMI\<24)

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What researchers measure

Primary outcomes

  1. absolute change in intramyocellular lipid quantity with exercise

    Time frame: over 4 months

07

Study locations

1 site
  • Univeresity of Minnesota
    Minneapolis, Minnesota 55455, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 24, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00786578
Lead sponsor
University of Minnesota
Collaborators
National Center for Research Resources (NCRR)
Responsible party
Sponsor
First posted
Nov 6, 2008
Start date
Jan 2010
Primary completion
Jan 2014
Completion
Jan 2014
Last update
Oct 24, 2014

Study contacts

Lisa S Chow
principal investigator · University of Minnesota

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.

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