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CompletedNCT00783731Updated Jul 26, 2011

Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

An interventional study of Low dose midazolam in Intubation, sponsored by Seoul National University Hospital. Completed at 2 sites in Korea, Republic of. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2011-07-26.

Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

02

Conditions studied

  • Intubation

Keywords

  • intubation
03

In context

Lead sponsor

Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • patients who need rapid sequence intubation in emergency room

Exclusion criteria

Exclusion Criteria:

  • in hypotension(systolic blood pressure less than 90 mmHg
  • severe trauma patients
  • pregnant
  • allergic to midazolam, etomidate
05

Study design

Phase
Not applicable
Primary purpose
Treatment

Study arms

  • Experimental
    Low dose midazolam

    Drug: Low dose midazolam

Interventions

  • DrugLow dose midazolam
06

Study locations

2 sites
  • Seoul National University Bundang Hospital, Emergency room
    Seongnam-si, Gyeonggi-do 463-707, Korea, Republic of
  • Boramae Medical Center
    Seoul, 156-707, Korea, Republic of
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 26, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00783731
Lead sponsor
Seoul National University Hospital
First posted
Nov 2, 2008
Start date
Oct 2008
Primary completion
Oct 2010
Completion
Jan 2011
Last update
Jul 26, 2011
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jul 2011. You cannot join it, but the record below documents what was studied.

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