An interventional study of Moderate Calcium, Low phytate Diet and Moderate Calcium, High Phytate Diet in Dietary Zinc Absorption, sponsored by USDA Grand Forks Human Nutrition Research Center. Completed at 1 site in United States. Open to female participants aged 21 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-02.
Sponsored by USDA Grand Forks Human Nutrition Research Center · Not applicable, Interventional, and Prevention
This study is determine the effects of dietary calcium and phytate on zinc absorption.
Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.
USDA Grand Forks Human Nutrition Research Center is the lead sponsor of 58 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants consumed 4 experimental diets for 4 weeks each in randomized order
Dietary Supplement: Moderate Calcium, Low phytate Diet · Dietary Supplement: Moderate Calcium, High Phytate Diet · Dietary Supplement: High Calcium, Low Phytate Diet · Dietary Supplement: High Calcium, High Phytate Diet
Participants consumed diet containing 700 milligrams calcium and 440 milligrams of phytate for 4 weeks
Participants consumed diet containing 700 milligrams calcium and 1800 milligrams of phytate for 4 weeks
Participants consumed diet containing 1900 milligrams calcium and 440 milligrams of phytate for 4 weeks
Participants consumed diet containing 1900 milligrams calcium and 1800 milligrams of phytate for 4 weeks
Zinc Absorption
Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time
Time frame: 16 weeks
Women were recruited by the United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center to participate in an out-patient feeding study in Grand Forks, North Dakota
| Milestone | Calcium and Phytate Interactions |
|---|---|
| Started | 17 |
| Completed | 12 |
| Not completed | 5 |
| Withdrew: Withdrawal by subject | 3 |
| Withdrew: Protocol violation | 2 |
| Milestone | Calcium and Phytate Interactions |
|---|---|
| Started | 12 |
| Completed | 12 |
| Not completed | 0 |
| Milestone | Calcium and Phytate Interactions |
|---|---|
| Started | 12 |
| Completed | 11 |
| Not completed | 1 |
| Withdrew: Protocol violation | 1 |
| Milestone | Calcium and Phytate Interactions |
|---|---|
| Started | 11 |
| Completed | 10 |
| Not completed | 1 |
| Withdrew: Protocol violation | 1 |
Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time
| Percentage of Zinc-65 absorbed | Moderate Calcium, Low Phytate Diet | Moderate Calcium, High Phytate Diet | High Calcium, Low Phytate Diet | High Calcium, High Phytate Diet |
|---|---|---|---|---|
| Zinc Absorption | 32.8 ± 2.3 | 26.9 ± 2.4 | 39.4 ± 2.4 | 26.2 ± 2.3 |
Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Overall Study | — | 0/17 (0%) | 0/17 (0%) |
| Age, Categorical(Participants) | Entire Study Population |
|---|---|
| <=18 years | 0 |
| Between 18 and 65 years | 17 |
| >=65 years | 0 |
| Age, Continuous(years) | Entire Study Population |
|---|---|
| Mean | 32.7 ± 9.5 |
| Sex: Female, Male(Participants) | Entire Study Population |
|---|---|
| Female | 17 |
| Male | 0 |
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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USDA Grand Forks Human Nutrition Research Center