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CompletedNCT00745303Updated Sep 3, 2008

Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects

An observational study in Healthy Subjects, sponsored by Taipei Veterans General Hospital, Taiwan. Completed at 1 site in Taiwan. Open to participants aged 50 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-09-03.

Sponsored by Taipei Veterans General Hospital, Taiwan · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
50
Ages
50 Years to 75 Years
Sex
All
01

Study summary

Since Tai Chi Chuan (TCC) training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects.

Read the detailed description

Tai Chi Chuan (TCC) is a traditional Oriental conditioning exercise or calisthenics that is believed by many people around the world to be good for the health. The frequently claimed reason for this merit of TCC is that it can improve the cardiopulmonary function and immunity of the subject who practice it continuously. TCC has been shown to delay the decline of aerobic power, improve the cardiopulmonary function, balance and strength of the subjects. One study has demonstrated that TCC could reduce tension, anxiety, and mood disturbance. However, few studies have examined the effect of TCC on the blood lipid profile and immunity of the TCC practitioners. Another study reported that 12-week programme of regular TCC exercise enhanced functional mobility, personal health expectations, and regulatory T cell function. It has also been shown that an appropriate combination of TCC exercise program with diabetic medication might improve both glucose metabolism and immunity in type 2 diabetic patients. Since TCC training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC may also have an effect on the blood lipid profile and immunity of the subjects. We hypothesize that TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects. Thus, the aim of this study was to examine whether or not TCC have these effects in the aged subjects.

02

Conditions studied

  • Healthy Subjects

Keywords

  • Tai Chi Chuan; Lipid; Cytokine
03

In context

Lead sponsor

Taipei Veterans General Hospital, Taiwan is the lead sponsor of 325 studies on the registry; 72 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Healthy aged subjects

Inclusion criteria

  • All subjects included in this study had normal lifestyles, and were capable of daily activities without limitations.

Exclusion criteria

Exclusion Criteria:

  • Subjects who had major cardiopulmonary disease or were on regular medicine for diabetes mellitus, hypertension, renal or liver disease were not included in the study.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
50 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • 1

    Subjects in this group received TCC training for 3 months

    Procedure: Tai Chi Cuan

  • 2

    Subjects in this group received no TCC training within 3 months

Interventions

  • ProcedureTai Chi Cuan

    Tai Chi Cuan training for 3 months

    Also known as: Yang's Tai Chi Cuan

06

What researchers measure

Primary outcomes

  1. TCC training for 3 months can improve the pulmonary function, glucose availability and lipid profile, and increase the cytokines production and vagal modulation in aged subjects.

    Time frame: 3 months

Secondary outcomes

  1. Other effects of TCC observed

    Time frame: 3 months

07

Study locations

1 site
  • Taipei Veterans General Hospital
    Taipei, 112, Taiwan
08

References and documents

Publications

  • Lu WA, Kuo CD. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc. 2003 Dec;35(12):1972-6. doi: 10.1249/01.MSS.0000099242.10669.F7. PubMed 14652490 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 3, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00745303
Lead sponsor
Taipei Veterans General Hospital, Taiwan
Collaborators
National Science Council, Taiwan
First posted
Sep 3, 2008
Start date
May 2002
Primary completion
May 2003
Completion
Mar 2004
Last update
Sep 3, 2008

Study contacts

Cheng-Deng Kuo, MD,PhD
principal investigator · Taipei Veterans General Hospital, Taiwan

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2008. You cannot join it, but the record below documents what was studied.

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