An observational study in Inflammatory Bowel Disease, sponsored by Tel-Aviv Sourasky Medical Center. Completed at 1 site in Israel. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2020-06-16.
Sponsored by Tel-Aviv Sourasky Medical Center · Observational
There is a reciprocal relationship between the central nervous system and the immune system. Stimulation of the vagus nerve results in secretion of acetylcholine (Ach) which decreases secretion of pro-inflammatory cytokines. Acetylcholine esterase is an enzyme that neutralizes Ach and thus, involves in regulation of Ach levels, and in the cholinergic tone and inflammatory state.
MicroRNAs (miRs) are evolutionarily conserved, RNAs that regulate gene expression. The investigators hypothesized that miRs controlling systemic communication processes function in one tissue in response to signals (i.e. neuronal, hormonal or others) from another.
Specifically, the investigators hypothesized that miRs control the inflammatory response in inflammatory bowel diseases through regulation of expression of messenger RNA of AchE.
964 studies on the registry are indexed under Intestinal Diseases; 176 are open to participants now.
This study's enrollment of 40 is below the median of 139 across 378 observational studies indexed under Intestinal Diseases.
Browse Intestinal Diseases studies →Tel-Aviv Sourasky Medical Center is the lead sponsor of 541 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients- inflammatory bowel disease patients under going colonoscopy controls- average risk patients without inflammation under going colonoscopy
Exclusion Criteria:
Inflammatory bowel disease patients
Average risk patients undergoing screening colonoscopy
Elevated expression of specific micro RNAs that regulate the expression of the enzyme Acetylcholine esterase in inflammatory bowel disease patients compared to healthy controls.
Time frame: one year
A statistically significant relation between micro RNA expression and disease activity and inflammatory indices
Time frame: one year
This study is completed, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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Tel-Aviv Sourasky Medical Center