Phase I/II Study of Z-208 in Advanced Hepatocellular Carcinoma (HCC)

• Histologically or cytologically confirmed hepatocellular carcinoma
• At least one measurable site of disease according to RECIST criteria that has not been irradiated.
• Child-Pugh classification A \& B
• ECOG performance status of 0-1
• Life expectancy is more than 90 days
• Adequate organ function as defined by the following criteria, Hemoglobin ≥ 8.0 g/dL WBC ≥ 3,000/mm\^3 \<12,000/mm\^3 Absolute neutrophil count ≥ 1,500/mm\^3 Platelet count ≥ 50,000/mm\^3 AST and ALT ≤ 5 times upper limit of normal (ULN) Albumin ≥ 2.8 g/dL Bilirubin ≤ 2.0 mg/dL Creatinine ≤ 1.5 times ULN
• Must provide written informed consent prior to the implementation of any study assessment or procedures

Exclusion criteria

• Patients received treatment with any of the following within the specified timeframe;Any surgical procedure, radiofrequency ablation, intraarterial chemotherapy within 30 days prior to signing the ICF, any treatment with transfusion, albumin preparation, G-CSF within 15 days prior to signing the ICF
• CNS involvement must have completed appropriate treatment
• Prior deep vein thrombosis
• Has ascites, pleural effusions or pericardial fluid refractory
• Active clinically serious infection excluding chronic hepatitis
• Any history of deep vein thrombosis, pulmonary embolism, myocardial infraction, cerebrovascular accident
• Allergy or hypersensitivity to Vitamin A
• Women who are pregnant or breast feeding