A Phase 2 interventional study of Inhalation of salbutamol diluted in hypertonic saline and Inhalation of salbutamol diluted in normal saline in Bronchiolitis and Respiratory Distress, sponsored by University Diego Portales. Status unknown at 1 site in Chile. Open to participants aged 1 Month to 24 Months. Per ClinicalTrials.gov, last updated 2008-06-12.
Sponsored by University Diego Portales · Phase 2, Interventional, and Treatment
We will study if small children who become ill with respiratory distress during the RSV epidemic are better relieved with salbutamol nebulizations diluted in hypertonic (3%), instead of normal (0.9%) saline.
In Santiago, Chile, a near collapse of health services is a notorious feature of every winter when vast numbers of small children line for attention because of respiratory distress caused by a probable RSV infection.
Our study will examine if nebulized salbutamol diluted in hypertonic (3%), instead of normal (0.9%) saline, provides better relief in outpatients.
If hypertonic saline proves safe and effective, the patients could be better managed and the pressure for attention diminished at a low cost, by a simple change in the saline ampule.
360 studies on the registry are indexed under Bronchiolitis; 43 are open to participants now.
This study's planned enrollment of 74 is close to the median of 80 across 249 interventional studies indexed under Bronchiolitis.
Browse Bronchiolitis studies →University Diego Portales is the lead sponsor of 8 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Salbutamol is diluted in hypertonic (3%) saline.
Drug: Inhalation of salbutamol diluted in hypertonic saline
Salbutamol is diluted in normal (0.9%) saline.
Drug: Inhalation of salbutamol diluted in normal saline
The first of 3 nebulizations of 0.5 mg of Salbutamol is diluted in 3.5 ml of hypertonic (3%) saline. The second and the third are diluted in normal (0.9%) saline.
Also known as: Albuterol diluted in hypertonic saline
The 3 nebulizations of 0.5 mg of Salbutamol are diluted in 3.5 ml of normal (0.9%) saline.
Also known as: Albuterol diluted in normal saline
Change in the respiratory distress score (Tal) between the basal score and the final score after 3 salbutamol nebulizations
Time frame: 1 hour
Change in the respiratory distress score (Tal) between the basal score and the first nebulization
Time frame: 15 to 20 minutes
Change in the respiratory distress score (Tal) between the basal score and the second nebulization
Time frame: 15 to 20 minutes after the first nebulization
Change in pulse oxymetry reading between the basal score and after each of the three nebulizations
Time frame: 1 hour
Change in cardiac frequency, irritability, general condition or anything else between the basal score and the first, second and third nebulization
Time frame: 1 hour
This study is status unknown, as verified in Jun 2008. You cannot join it, but the record below documents what was studied.
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University Diego Portales