An interventional study of Calcium Carbonate in Obesity, sponsored by USDA, Western Human Nutrition Research Center. Completed at 1 site in United States. Open to female participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-07-22.
Sponsored by USDA, Western Human Nutrition Research Center · Not applicable, Interventional, and Prevention
We hope to determine if supplementing the diet of women who habitually consume low levels of calcium, with 1500 mg of calcium a day for three months will increase fat oxidation and decrease fat storage. We will also measure concentrations of lipids, glucose, hormones and enzymes associated with fat and carbohydrate metabolism to determine alterations and mechanism of the metabolic changes.
The incidence of obesity has rapidly increased in recent years and reached epidemic proportions in the United States. Recent epidemiological data has shown an inverse relationship between calcium intake and body fat and emerging research suggests that inadequate dietary calcium consumption may increase obesity. Studies in mice have shown that an increase in dietary calcium consumption creates a shift in the utilization of energy stores from carbohydrates to fat and a shift in the partitioning of energy from storage (as fat) to expenditure (as heat).
We will give 1500 mg of calcium a day for three months to women who habitually consume low levels of dietary calcium. The following measurements will be made before and after calcium supplementation: body fat by DEXA, lipolysis by infusion of stable isotopes of 1,1,2,3,3-[2H5] glycerol , hepatic glucose production by infusion of stable isotopes of 6,6-[2H2] glucose, lipogenesis by measurement of fatty acid synthase activity (14C radiochemical assay) , mRNA expression ( Real Time Polymerase Chain Reaction) and protein content (ELISA), indirect calorimetry measurement of non-protein respiratory quotient (NPRQ), energy expenditure, fat and carbohydrate oxidation. Serum calcium, glucose, cholesterol, triglycerides, LDL, HDL, parathyroid hormone, leptin, free fatty acids, adiponectin, 1,25(OH)2D, 25(OH)D and urinary calcium excretion will also be measured.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 15 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
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Exclusion Criteria:
1500 mg per day
Lipolysis by infusion of stable isotopes of 1,1,2,3,3-[2H5] glycerol
Time frame: 0 and 3 months
Hepatic glucose production by infusion of stable isotopes of 6,6-[2H2] glucose
Time frame: 0 and 3 months
Lipogenesis by measurement of fatty acid synthase activity (14C radiochemical assay) , mRNA expression ( Real Time Polymerase Chain Reaction) and protein content (ELISA)
Time frame: 0 and 3 months
Indirect calorimetry measurement of non-protein respiratory quotient (NPRQ), energy expenditure, fat and carbohydrate oxidation
Time frame: 0 and 3 months
Serum calcium, glucose, cholesterol, triglycerides, LDL, HDL, parathyroid hormone, leptin, free fatty acids, adiponectin, 1,25(OH)2D, 25(OH)D
Time frame: 0 and 3 months
urinary calcium and sodium excretion
Time frame: 0 and 3 months
This study is completed, as verified in May 2008. You cannot join it, but the record below documents what was studied.
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USDA, Western Human Nutrition Research Center