CClinicalTrials.gg
CompletedNCT00683397Updated Apr 19, 2017

Frankfurt Thrombophilia Registry

An observational study in Venous Thromboembolism, sponsored by Cardioangiologisches Centrum Bethanien. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-04-19.

Sponsored by Cardioangiologisches Centrum Bethanien · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
2,000
Ages
18 Years and older
Sex
All
01

Study summary

Consecutive patients with acute or previous venous thromboembolism are enrolled in this registry. Using a standardized questionnaire, clinical data detailing venous thromboembolism and contributing VTE risk factors are recorded. Results of technical and laboratory investigations including screening for thrombophilic disorders were additionally entered into the database.

02

Conditions studied

  • Venous Thromboembolism

Keywords

  • assess
  • prevalence
  • thrombophilia
  • common
  • VTE
  • risk factors
  • patients
03

In context

Thromboembolism

818 studies on the registry are indexed under Thromboembolism; 98 are open to participants now.

This study's enrollment of 2,000 is above the median of 500 across 344 observational studies indexed under Thromboembolism.

Browse Thromboembolism studies →

Lead sponsor

Cardioangiologisches Centrum Bethanien is the lead sponsor of 16 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

consecutive patients with acute or previous VTE >18 years of age

Inclusion criteria

  • Acute or previous VTE

Exclusion criteria

Exclusion Criteria:

  • None
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
2,000 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • A

    Patients with acute or previous venous thromboembolism \>18 years of age

    Other: Blood sampling

Interventions

  • OtherBlood sampling

    Screening of thrombophilia

06

Study locations

1 site
  • Cardioangiologisches Centrum Bethanien
    Frankfurt/Main, Hessen 60389, Germany
07

References and documents

Publications

  • Kraft C, Schuettfort G, Weil Y, Tirneci V, Kasper A, Haberichter B, Schwonberg J, Schindewolf M, Lindhoff-Last E, Linnemann B. Thrombosis of the inferior vena cava and malignant disease. Thromb Res. 2014 Sep;134(3):668-73. doi: 10.1016/j.thromres.2014.07.012. Epub 2014 Jul 18. PubMed 25081831 ↗
  • Linnemann B, Kraft C, Roskos M, Zgouras D, Lindhoff-Last E. Inferior vena cava thrombosis and its relationship with the JAK2V617F mutation and chronic myeloproliferative disease. Thromb Res. 2012 Jun;129(6):720-4. doi: 10.1016/j.thromres.2011.09.011. Epub 2011 Oct 7. PubMed 21982959 ↗
  • Schimanski S, Linnemann B, Luxembourg B, Seifried E, Jilg W, Lindhoff-Last E, Schambeck CM. Cytomegalovirus infection is associated with venous thromboembolism of immunocompetent adults--a case-control study. Ann Hematol. 2012 Apr;91(4):597-604. doi: 10.1007/s00277-011-1334-9. Epub 2011 Sep 9. PubMed 21913128 ↗
  • Luxembourg B, Schmitt J, Humpich M, Glowatzki M, Dressler D, Seifried E, Lindhoff-Last E. Cardiovascular risk factors in idiopathic compared to risk-associated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP). Thromb Haemost. 2009 Oct;102(4):668-75. doi: 10.1160/TH-09-02-0104. PubMed 19806251 ↗
  • Luxembourg B, Schmitt J, Humpich M, Glowatzki M, Seifried E, Lindhoff-Last E. Intrinsic clotting factors in dependency of age, sex, body mass index, and oral contraceptives: definition and risk of elevated clotting factor levels. Blood Coagul Fibrinolysis. 2009 Oct;20(7):524-34. doi: 10.1097/MBC.0b013e32832d9b58. PubMed 19620844 ↗
  • Weingarz L, Schindewolf M, Schwonberg J, Hecking C, Wolf Z, Erbe M, Lindhoff-Last E, Linnemann B. Thrombophilia and risk of VTE recurrence according to the age at the time of first VTE manifestation. Vasa. 2015 Jul;44(4):313-23. doi: 10.1024/0301-1526/a000447. PubMed 26314364 ↗
  • Linnemann B, Weingarz L, Schindewolf M, Schwonberg J, Weber A, Herrmann E, Lindhoff-Last E. Prevalence of established risk factors for venous thromboembolism according to age. J Vasc Surg Venous Lymphat Disord. 2014 Apr;2(2):131-9. doi: 10.1016/j.jvsv.2013.09.006. Epub 2014 Jan 16. PubMed 26993177 ↗
  • Weingarz L, Schwonberg J, Schindewolf M, Hecking C, Wolf Z, Erbe M, Weber A, Lindhoff-Last E, Linnemann B. Prevalence of thrombophilia according to age at the first manifestation of venous thromboembolism: results from the MAISTHRO registry. Br J Haematol. 2013 Dec;163(5):655-65. doi: 10.1111/bjh.12575. Epub 2013 Oct 8. PubMed 24219332 ↗
  • Kraft C, Hecking C, Schwonberg J, Schindewolf M, Lindhoff-Last E, Linnemann B. Patients with inferior vena cava thrombosis frequently present with lower back pain and bilateral lower-extremity deep vein thrombosis. Vasa. 2013 Jul;42(4):275-83. doi: 10.1024/0301-1526/a000288. PubMed 23823859 ↗
  • Linnemann B, Meister F, Schwonberg J, Schindewolf M, Zgouras D, Lindhoff-Last E; MAISTHRO registry. Hereditary and acquired thrombophilia in patients with upper extremity deep-vein thrombosis. Results from the MAISTHRO registry. Thromb Haemost. 2008 Sep;100(3):440-6. PubMed 18766260 ↗
  • Berger M, Moscatelli H, Kulle B, Luxembourg B, Blouin K, Spannagl M, Lindhoff-Last E, Schambeck CM. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. Thromb Haemost. 2008 May;99(5):905-8. doi: 10.1160/TH08-01-0059. PubMed 18449420 ↗
  • Linnemann B, Schmidt H, Schindewolf M, Erbe M, Zgouras D, Grossmann R, Schambeck C, Lindhoff-Last E. Etiology and VTE risk factor distribution in patients with inferior vena cava thrombosis. Thromb Res. 2008;123(1):72-8. doi: 10.1016/j.thromres.2008.01.004. Epub 2008 Mar 4. PubMed 18295303 ↗
  • Linnemann B, Zgouras D, Schindewolf M, Schwonberg J, Jarosch-Preusche M, Lindhoff-Last E. Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry. Blood Coagul Fibrinolysis. 2008 Mar;19(2):159-65. doi: 10.1097/MBC.0b013e3282f54558. PubMed 18277138 ↗
  • Linnemann B, Schindewolf M, Zgouras D, Erbe M, Jarosch-Preusche M, Lindhoff-Last E. Are patients with thrombophilia and previous venous thromboembolism at higher risk to arterial thrombosis? Thromb Res. 2008;121(6):743-50. doi: 10.1016/j.thromres.2007.07.014. Epub 2007 Sep 4. PubMed 17804043 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 19, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00683397
Lead sponsor
Cardioangiologisches Centrum Bethanien
Responsible party
Prof. Dr. med. E. Lindhoff-Last (M.D., Cardioangiologisches Centrum Bethanien) — Principal investigator
First posted
May 23, 2008
Start date
May 2008
Primary completion
Dec 2014
Completion
Dec 2014
Last update
Apr 19, 2017

Study contacts

Edelgard Lindhoff-Last, Professor
principal investigator · Cardioangiologisches Zentrum Bethanien
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion