A Phase 4 interventional study of surgical technique: duct-to-duct biliary reconstruction and surgical technique: roux-en-y biliary reconstruction in Liver Transplantation, sponsored by University Health Network, Toronto. Status unknown at 1 site in Canada. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2014-07-25.
Sponsored by University Health Network, Toronto · Phase 4, Interventional, and Prevention
The purpose of this study is to empirically determine whether one of 2 surgical techniques commonly used for bile duct reconstruction during living donor liver transplantation results in fewer biliary complications. Also, this study may identify patient group(s) that particularly benefit from a particular technique.
The purpose of this study is to compare the incidence of biliary complications (bile leaks and strictures) following duct-to-duct and roux-en-y biliary reconstruction during right lobe living donor liver transplantation.
Biliary complications are much more common with right lobe living donor liver grafts than with whole organ grafts and are considered a major limitation of this surgery. Two surgical techniques are currently used for biliary reconstruction and each has its advantages/disadvantages. However, it is unclear which technique leads to fewer biliary complications. Retrospective studies which examine biliary complication rates may be hampered by such factors as a surgeon's bias or inexperience with a particular technique. Therefore a prospective randomized trial is needed.
University Health Network, Toronto is the lead sponsor of 1,411 studies on the registry; 292 are open to participants now.
Of its 17 completed or terminated interventional studies of FDA-regulated products, 3 (18%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Procedure: surgical technique: duct-to-duct biliary reconstruction
Procedure: surgical technique: roux-en-y biliary reconstruction
surgical reconstruction
surgical reconstruction
Biliary complications defined as leaks and strictures within the first year post LDLT;
Time frame: 1 year
Graft and patient survival
Time frame: 1 year post-transplant
Length of hospital-stay and ICU-stay
Time frame: within first 30 days after discharge
Any infection or rejection episodes
Time frame: 1 year post- transplant
time to full oral nutrition
Time frame: within 30 days of discharge
This study is status unknown, as verified in Jun 2012. You cannot join it, but the record below documents what was studied.
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University Health Network, Toronto