A Phase 2 interventional study of sodium bicarbonate and Acetazolamide in Contrast Induced Nephropathy, sponsored by Shiraz University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-03-13.
Sponsored by Shiraz University of Medical Sciences · Phase 2, Interventional, and Prevention
The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy
Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
This study's enrollment of 240 is above the median of 70 across 2,640 interventional studies indexed under Kidney Diseases.
Browse Kidney Diseases studies →Shiraz University of Medical Sciences is the lead sponsor of 129 studies on the registry; 6 are open to participants now.
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Exclusion Criteria:
150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography
Drug: sodium bicarbonate
Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography
Drug: Acetazolamide
normal salin 1cc/kg/hr before and after angiography
Drug: normal salin
150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography
Also known as: no other name
Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography
Also known as: Diamox
1 cc/kg/hr 6 hour before and after angiography
Also known as: no other name
Increased base line creatinine at least 25%
Time frame: 24 hr later
This study is completed, as verified in Mar 2008. You cannot join it, but the record below documents what was studied.
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Shiraz University of Medical Sciences